Bagshaw M A, Ray G R, Cox R S
Urology. 1985 Feb;25(2 Suppl):17-23.
Results of a study that began at Stanford in 1956 demonstrate that long-term, disease-free survival can be achieved following appropriate irradiation in patients with prostatic carcinoma. However, the investigation has also uncovered several powerful prognostic indicators, such as the extent of anatomic involvement, histologic pattern, particularly as described by Gleason; and presence or absence of lymphnode metastases. To illustrate the importance of these parameters, the author presents data that correlate survival with the anatomic extent of the primary tumor and the Gleason pattern scores. Of the staged patients, 64 have been subjected to post-therapeutic biopsy of the prostate 18 months or more following therapy. A correlation also seems to exist among clinical stage, lymph node involvement, and subsequent biopsy status. The implication of this finding in the development of more aggressive therapeutic approaches will be discussed.
一项于1956年在斯坦福大学开展的研究结果表明，前列腺癌患者在接受适当的放射治疗后可实现长期无病生存。然而，该调查还发现了几个有力的预后指标，如解剖学受累程度、组织学模式，特别是如Gleason所描述的那样；以及有无淋巴结转移。为了说明这些参数的重要性，作者呈现了将生存情况与原发肿瘤的解剖学范围和Gleason模式评分相关联的数据。在已分期的患者中，有64例在治疗后18个月或更长时间接受了前列腺治疗后活检。临床分期、淋巴结受累情况和后续活检状态之间似乎也存在关联。将讨论这一发现对制定更积极治疗方法的意义。
