Irawan Dita Mutiara, Lesmana Ronny, Sahiratmadja Edhyana
Graduate School of Master Program in Anti Aging and Aesthetic Medicine, Faculty of Medicine, Universitas Padjadjaran, Jatinangor, 45363, Indonesia.
Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Jatinangor, 45363, Indonesia.
Clin Cosmet Investig Dermatol. 2024 Aug 19;17:1853-1861. doi: 10.2147/CCID.S468494. eCollection 2024.
People who suffered type 2 diabetes have impaired healing of wounds due to the large number of circulating inflammatory cells resulting from high blood sugar levels. The wound healing process involves various complex processes including the degradation of extracellular matrix, a process characterized by an increase in matrix metalloproteinase-9 (MMP-9). Conventional management of diabetic wounds usually involves systemic blood sugar control and topical antimicrobial treatment, including hydrogen peroxide and povidone-iodine, which are known to be cytotoxic to the cells involved in the wound healing cascade. Finding a safe, non-toxic, and effecting wound cleansing still poses a challenge, and hypochlorous acid (HOCl) could act as a potential candidate.
Unveiling an HOCl ion as an agent for diabetic wound management and MMP-9 as a marker for delayed diabetic wound healing.
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Flow Diagram is used to find and select related, eligible literatures for the review. The authors used several databases such as Pro Quest, Scopus, Springer link and Science Direct. In addition, and to expand the data, the database on Google Scholar was also opened. Then, the compiled data are analyzed to form results and discussions to the research question.
Five eligible articles passed the inclusion criteria and reviewed for data synthesis. From 5 pieces of literature, it was found that the use of HOCl ions can be a good choice of topical agent in the management of diabetic wounds and decrease the activity of MMP-9, which act as a marker for delayed healing of diabetic wounds.
Topical agent, in this case HOCl ion, shows good results and can be used as an option in the management of diabetic wounds and MMP-9 can be used as a predictive marker in the management of diabetic wounds.
2型糖尿病患者由于高血糖水平导致大量循环炎症细胞，伤口愈合受损。伤口愈合过程涉及各种复杂过程，包括细胞外基质的降解，这一过程的特征是基质金属蛋白酶-9（MMP-9）增加。糖尿病伤口的传统管理通常包括全身血糖控制和局部抗菌治疗，包括过氧化氢和聚维酮碘，已知它们对伤口愈合级联反应中涉及的细胞具有细胞毒性。找到一种安全、无毒且有效的伤口清洁方法仍然是一个挑战，而次氯酸（HOCl）可能是一个潜在的选择。
揭示次氯酸根离子作为糖尿病伤口管理的一种药物，以及MMP-9作为糖尿病伤口愈合延迟的一个标志物。
使用系统评价和Meta分析的首选报告项目（PRISMA）流程图来查找和选择相关的合格文献进行综述。作者使用了几个数据库，如Pro Quest、Scopus、Springer link和Science Direct。此外，为了扩展数据，还打开了谷歌学术数据库。然后，对汇编的数据进行分析，以形成对研究问题的结果和讨论。
五篇符合条件的文章通过了纳入标准，并进行了数据综合审查。从5篇文献中发现，使用次氯酸根离子可以是糖尿病伤口管理中局部用药的一个好选择，并降低MMP-9的活性，MMP-9是糖尿病伤口愈合延迟的一个标志物。
局部用药，在这种情况下是次氯酸根离子，显示出良好的效果，可以作为糖尿病伤口管理的一种选择，而MMP-9可以作为糖尿病伤口管理中的一个预测标志物。
