Solopov Pavel A, Biancatelli Ruben Manuel Luciano Colunga, Day Tierney, Dimitropoulou Christiana, Catravas John D
Res Sq. 2024 Aug 13:rs.3.rs-4758497. doi: 10.21203/rs.3.rs-4758497/v1.
Hydrochloric acid is one of the most prevalent and dangerous chemicals. Accidental spills occur in industrial plants or during transportation. Exposure to HCl can induce severe health impairment, including acute and chronic pulmonary diseases. We have previously described the molecular, structural, and functional aspects of the development of chronic lung injury and pulmonary fibrosis caused by intratracheal instillation of HCl in mice. Although mouse models of human disease have many advantages, rodents are evolutionary far from human and exhibit significant anatomical and physiological differences. Genetic and anatomic similarities between rabbits and humans are significantly higher. Rabbit models of HCl-induced lung injury have been used sparsely to evaluate acute lung injury. In this study, for the first time, we utilized rabbits as a model of HCl-induced pulmonary fibrosis and chronic lung injury. We present molecular, histological, and functional evidence that demonstrate the utility of using this model for studying new pharmaceutics against pulmonary fibrosis.
盐酸是最常见且危险的化学品之一。在工厂或运输过程中会发生意外泄漏。接触盐酸会导致严重的健康损害，包括急慢性肺部疾病。我们之前已经描述了通过气管内注入盐酸在小鼠中引起的慢性肺损伤和肺纤维化发展的分子、结构和功能方面。尽管人类疾病的小鼠模型有许多优点，但啮齿动物在进化上与人类相差甚远，并且表现出明显的解剖学和生理学差异。兔子与人类之间的遗传和解剖学相似性要高得多。盐酸诱导的肺损伤兔子模型已很少用于评估急性肺损伤。在本研究中，我们首次将兔子用作盐酸诱导的肺纤维化和慢性肺损伤模型。我们提供了分子、组织学和功能证据，证明使用该模型研究抗肺纤维化新药物的实用性。
