Frank Reidy Research Center in Bioelectrics, Old Dominion University, Norfolk, VA, USA.
Division of Pulmonary and Critical Care, Department of Internal Medicine, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA, USA.
Respir Res. 2024 Oct 29;25(1):390. doi: 10.1186/s12931-024-03022-7.
Hydrochloric acid is one of the most prevalent and hazardous chemicals. Accidental spills occur in industrial plants or during transportation. Exposure to HCl can induce severe health impairment, including acute and chronic pulmonary diseases. We have previously described the molecular, structural, and functional aspects of the development of chronic lung injury and pulmonary fibrosis caused by intratracheal instillation of HCl in mice. Although mouse models of human disease have many advantages, rodents are evolutionary far from human and exhibit significant anatomical and physiological differences. Genetic and anatomic similarities between rabbits and humans are significantly higher. Rabbit models of HCl-induced lung injury have been used sparsely to evaluate acute lung injury. In this study, for the first time, we utilized rabbits as a model of HCl-induced pulmonary fibrosis and chronic lung injury. We present molecular, histological, and functional evidence that demonstrate the utility of using this model for studying new pharmaceutics against pulmonary fibrosis.
盐酸是最常见和危险的化学物质之一。在工业工厂或运输过程中会发生意外泄漏。接触 HCl 会引起严重的健康损害，包括急性和慢性肺部疾病。我们之前已经描述了在小鼠中通过气管内滴注 HCl 引起的慢性肺损伤和肺纤维化的分子、结构和功能方面。尽管人类疾病的小鼠模型有许多优点，但啮齿动物在进化上与人类相去甚远，表现出明显的解剖和生理差异。兔子和人类之间的遗传和解剖相似性要高得多。兔模型的 HCl 诱导的肺损伤很少用于评估急性肺损伤。在这项研究中，我们首次利用兔子作为 HCl 诱导的肺纤维化和慢性肺损伤模型。我们提供了分子、组织学和功能证据，证明了使用这种模型来研究新的抗肺纤维化药物的效用。
