Mulat Getie, Maru Moges, Tarekegn Zewdu Seyoum, Dejene Haileyesus
Department of Veterinary Pathobiology, College of Veterinary Medicine and Animal Sciences, University of Gondar, Ethiopia.
Department of Veterinary Epidemiology and Public Health, College of Veterinary Medicine and Animal Sciences, University of Gondar, Ethiopia.
Parasite Epidemiol Control. 2024 Jul 29;26:e00371. doi: 10.1016/j.parepi.2024.e00371. eCollection 2024 Aug.
Bovine trypanosomosis is an incapacitating and lethal ailment brought about by protozoan parasites of the genus Trypanosoma. The disease leads to losses in livestock and agricultural productivity, resulting in significant socio-economic repercussions. In East Africa, trypanosomosis has been endemic for an extensive period due to ecological factors and vector biology that facilitate the persistent circulation of trypanosomes. This investigation outlines the occurrence of bovine trypanosomosis in East Africa through a meta-analysis. A thorough search was conducted on PubMed, Google Scholar, Scopus, Web of Science and AJOL. Suitable studies were chosen using inclusion and exclusion criteria. The prevalence was estimated through a random effect model. Publication bias and the variation in prevalence estimates due to heterogeneity were also evaluated. The analysis was performed on 115 studies that contained relevant prevalence data. The collective estimate of bovine trypanosomosis prevalence across the studies stood at 12% (95% CI: 11, 13), ranging from 1% (95% CI: 0, 2) to 51% (95% CI: 45, 58). The subgroup analysis by country revealed considerable disparities in prevalence. The highest estimated prevalence was 24% (95% CI: 18, 30) in Somalia, whereas the lowest prevalence was observed in Ethiopia at 10% (95% CI: 9, 11). A significant level of heterogeneity was noted in most pooled estimates, even after conducting subgroup analysis. The visual examination of the funnel plot and the Egger's regression asymmetry coefficient (b = -5.13, 95% CI: -7.49, -2.76, = 0.00) and Begg's plot ( = 0.00) indicate the presence of publication bias. In conclusion, bovine trypanosomosis is a pervasive and noteworthy malady affecting livestock. The findings of this investigation imply a high prevalence of bovine trypanosomosis in the majority of the countries under scrutiny. Despite the well-known hindrance that livestock trypanosomosis poses to livestock production in Africa, little attention has been devoted to the trypanosomosis situation, particularly in East African nations.
牛锥虫病是由锥虫属原生动物寄生虫引起的一种使人衰弱和致命的疾病。这种疾病会导致牲畜损失和农业生产力下降，从而产生重大的社会经济影响。在东非，由于有利于锥虫持续传播的生态因素和媒介生物学特性，锥虫病长期以来一直流行。本调查通过荟萃分析概述了东非牛锥虫病的发生情况。对PubMed、谷歌学术、Scopus、科学网和非洲期刊在线进行了全面搜索。使用纳入和排除标准选择合适的研究。通过随机效应模型估计患病率。还评估了发表偏倚以及由于异质性导致的患病率估计值的变化。对115项包含相关患病率数据的研究进行了分析。各项研究中牛锥虫病患病率的总体估计为12%（95%置信区间：11，13），范围从1%（95%置信区间：0，2）到51%（95%置信区间：45，58）。按国家进行的亚组分析显示患病率存在显著差异。估计患病率最高的是索马里，为24%（95%置信区间：18，30），而埃塞俄比亚的患病率最低，为10%（95%置信区间：9，11）。即使在进行亚组分析后，大多数汇总估计中仍存在显著的异质性水平。漏斗图的视觉检查以及埃格回归不对称系数（b = -5.13，95%置信区间：-7.49，-2.76，P = 0.00）和贝格图（P = 0.00）表明存在发表偏倚。总之，牛锥虫病是一种影响牲畜的普遍且值得关注的疾病。本调查结果表明，在所审查的大多数国家中，牛锥虫病的患病率很高。尽管牲畜锥虫病对非洲的牲畜生产构成了众所周知的障碍，但对锥虫病情况的关注很少，特别是在东非国家。
