Workineh Yinager, Semachew Ayele, Ayalew Emiru, Animaw Worku, Tirfie Mulat, Birhanu Minychil
Department of Child Health Nursing, College of Medicine and Health Sciences, Bahir Dar University, Ethiopia.
Department of Adult Health Nursing, College of Medicine and Health Sciences, Bahir Dar University, Ethiopia.
Heliyon. 2020 Apr 26;6(4):e03793. doi: 10.1016/j.heliyon.2020.e03793. eCollection 2020 Apr.
Birth asphyxia leads to about 4 million neonatal deaths every year around the globe. But, the pooled prevalence of asphyxia was not yet collated in East and Central African countries. Hence, this systematic review and meta-analysis aimed to determine the pooled prevalence of perinatal asphyxia in Central and East Africa.
PubMed, Google Scholar, Science Direct, Africa Index Medicus, Africa Journal Online, Excerpta Medica Database, and Cochrane Library databases were searched. All necessary data were extracted using a standardized data extraction format. Data were analyzed using STATA 14 statistical software. A heterogeneity of studies was assessed using the I statistics. Publication bias was checked by using a funnel plot and Egger's regression test. A random-effect model was computed to estimate the pooled prevalence of perinatal asphyxia.
Thirteen full-text studies were included in the present meta-analysis. The pooled prevalence of perinatal asphyxia in this study was 15.9% (95%CI: 10.8, 21.0% [I = 94.6, p = 0.000]). Regional subgroup analysis indicated that the pooled prevalence of perinatal asphyxia was 18.0 % (95%CI:11.4, 26.7% [I = 96.00, p = 0.000]) and 9.1 % (95%CI:2.0, 16.2% [I = 90.80, P = 0.000]) in East and Central African countries respectively. Similarly, the level of perinatal asphyxia was varied based on asphyxia measuring tools. But the trim fill analysis pointed that there was no difference in the pooled prevalence of perinatal asphyxia in this study.
The pooled prevalence of perinatal asphyxia was high in the current study. It had also substantial variation across the regions and measuring tools. Therefore, there is a call to reduce the high burden of this problem in the region.
全球范围内，出生窒息每年导致约400万新生儿死亡。但是，东非和中非国家窒息的合并患病率尚未得到整理。因此，本系统评价和荟萃分析旨在确定中非和东非围产期窒息的合并患病率。
检索了PubMed、谷歌学术、科学Direct、非洲医学索引、非洲在线期刊、医学文摘数据库和考科蓝图书馆数据库。使用标准化的数据提取格式提取所有必要数据。使用STATA 14统计软件进行数据分析。使用I统计量评估研究的异质性。通过漏斗图和埃格回归检验检查发表偏倚。计算随机效应模型以估计围产期窒息的合并患病率。
本荟萃分析纳入了13项全文研究。本研究中围产期窒息的合并患病率为15.9%（95%CI：10.8，21.0%[I=94.6，p=0.000]）。区域亚组分析表明，东非和中非国家围产期窒息的合并患病率分别为18.0%（95%CI：11.4，26.7%[I=96.00，p=0.000]）和9.1%（95%CI：2.0，16.2%[I=90.80，P=0.000]）。同样，围产期窒息水平因窒息测量工具而异。但修剪填充分析指出，本研究中围产期窒息的合并患病率没有差异。
本研究中围产期窒息的合并患病率较高。而且在不同地区和测量工具之间也存在很大差异。因此，需要降低该地区这一问题的高负担。
