Department of Internal Medicine, University of Health Sciences-Adana Health Practice and Research Center, Adana, Turkey.
PeerJ. 2024 Aug 22;12:e17905. doi: 10.7717/peerj.17905. eCollection 2024.
In our study, we aimed to investigate the Achilles tendon thickness (ATT) and asprosin levels in patients with polycystic ovary syndrome (PCOS) and to evaluate the relationship of these parameters, which may be related to cardio-metabolic diseases.
In our prospective cross-sectional study, 45 female patients with PCOS and 30 female healthy individuals similar in age were included. Serum dehydroepiandrosterone sulfate (DHEAS), total testosterone, anti-Müllerian hormone (AMH) and asprosin levels were measured using appropriate kits and homeostatic model assessment of insulin resistance (HOMA-IR), luteinizing hormone (LH) to follicle-stimulating hormone (FSH) ratio was calculated. ATT measurements were performed by two radiologists using a high-resolution ultrasound doppler system.
Serum DHEAS, total testosterone, AMH and asprosin levels, HOMA-IR value, LF/FSH ratio, and ATT values were higher in patients with PCOS compared to healthy controls. Correlation analysis was performed between ATT and other parameters in patients with PCOS. In univariate analysis, parameters associated with ATT were detected as asprosin, DHEAS and AMH. In the linear regression analysis performed with significant parameters, asprosin and DHEAS levels were found to be associated with ATT.
ATT values and serum asprosin levels were found to be significantly increased in patients with PCOS, and there is a very close positive relationship between ATT and serum asprosin levels. For this reason, it was thought that ATT measurement could be a cheap, simple and non-invasive monitoring parameter that can be used in the routine cardiometabolic follow-up of patients with PCOS.
在我们的研究中，我们旨在研究多囊卵巢综合征（PCOS）患者的跟腱厚度（ATT）和天冬氨酸蛋白酶原（asprosin）水平，并评估这些参数之间的关系，这些参数可能与心脏代谢疾病有关。
在我们的前瞻性横断面研究中，纳入了 45 名多囊卵巢综合征患者和 30 名年龄相似的健康女性。使用适当的试剂盒测量血清脱氢表雄酮硫酸酯（DHEAS）、总睾酮、抗苗勒氏管激素（AMH）和天冬氨酸蛋白酶原水平，并计算胰岛素抵抗的稳态模型评估（HOMA-IR）、黄体生成素（LH）与卵泡刺激素（FSH）比值。使用高分辨率超声多普勒系统由两名放射科医生进行 ATT 测量。
与健康对照组相比，PCOS 患者的血清 DHEAS、总睾酮、AMH 和 asprosin 水平、HOMA-IR 值、LH/FSH 比值和 ATT 值较高。对 PCOS 患者的 ATT 与其他参数进行了相关性分析。在单变量分析中，与 ATT 相关的参数被检测为 asprosin、DHEAS 和 AMH。在对有意义参数进行的线性回归分析中，发现 asprosin 和 DHEAS 水平与 ATT 相关。
PCOS 患者的 ATT 值和血清 asprosin 水平显著升高，ATT 与血清 asprosin 水平之间存在非常密切的正相关关系。因此，认为 ATT 测量可能是一种廉价、简单、非侵入性的监测参数，可以用于 PCOS 患者的常规心脏代谢随访。
