Yuen B H, Pride S M, Rowe T C, Moon Y S, McComb P F, Poland B J, Gomel V
Am J Obstet Gynecol. 1985 Jan 15;151(2):172-5. doi: 10.1016/0002-9378(85)90005-5.
A low-dose "nonsuperovulation" scheme of ovulation induction (schedule 1: 15 treatment cycles in 13 women) was compared to a high-dose, individually adjusted "controlled-superovulation" scheme of human menopausal gonadotropin administration (schedule 2: 18 treatment cycles in 17 women, with four women also having been treated under schedule 1). In schedule 2 more human menopausal gonadotropin was employed, 17 beta-estradiol plasma levels were higher, and more ova were retrieved per treatment cycle (p less than 0.01) with a higher rate of mature ova (p = 0.001). Also, under this schedule all treatment cycles resulted in successful retrieval of ova, whereas under schedule 1, four cycles (27%) were abandoned before laparoscopy because the follicles had ovulated (p = 0.03). Furthermore, the proportion of embryos cleaving to the two- to four-cell stage were higher under schedule 2 (38 of 53, or 72%) as compared to schedule 1 (13 of 25, or 52%), but this was not statistically significant (p = 0.07). Two pregnancies were conceived under schedule 2 giving a rate of 11% per treatment cycle. It was concluded that schedule 2, the individually adjusted controlled-superovulation scheme of human menopausal gonadotropin administration, was the superior technique of ovulation induction in an in vitro fertilization program.
将低剂量“非超排卵”促排卵方案（方案1：13名女性进行15个治疗周期）与高剂量、个体化调整的人绝经期促性腺激素给药“控制性超排卵”方案（方案2：17名女性进行18个治疗周期，其中4名女性也接受过方案1的治疗）进行比较。在方案2中，使用了更多的人绝经期促性腺激素，血浆17β -雌二醇水平更高，每个治疗周期回收的卵子更多（p<0.01），成熟卵子率更高（p = 0.001）。此外，在该方案下所有治疗周期均成功回收卵子，而在方案1中，有4个周期（27%）在腹腔镜检查前被放弃，因为卵泡已排卵（p = 0.03）。此外，与方案1（25个中的13个，即52%）相比，方案2下卵裂至2 - 4细胞期的胚胎比例更高（53个中的38个，即72%），但这无统计学意义（p = 0.07）。方案2下有2例妊娠，每个治疗周期的妊娠率为11%。得出的结论是，方案2，即个体化调整的人绝经期促性腺激素给药控制性超排卵方案，是体外受精程序中更优越的促排卵技术。
