Fluker M R, Siu C K, Gunby J, Daya S
Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada.
J Assist Reprod Genet. 1993 Nov;10(8):504-12. doi: 10.1007/BF01204360.
This retrospective analysis of 148 non-male factor couples sought to determine whether oocyte or embryonic quality was compromised by the magnitude of the ovarian response following clomiphene citrate/human menopausal gonadotropin stimulation for in vitro fertilization.
Increased oocyte numbers were associated with decreased fertilization rates (r = -0.36, P < 0.001) and estradiol/follicle ratios (r = -0.443, P < 0.001), although the quality of the resulting embryos was not affected. Despite reduced fertilization, higher oocyte numbers yielded additional healthy embryos (r = 0.70, P < 0.001) for immediate replacement or cryopreservation. Implantation rates did not differ among groups and no predictive variables were identified.
These results suggest that endometrial receptivity and implantation were not adversely affected by increasing estradiol levels. The decline in oocyte quality associated with the retrieval of larger numbers of oocytes appeared to be offset by the availability of additional embryos for immediate replacement and cryopreservation.
这项对148对非男性因素夫妇的回顾性分析旨在确定，在使用枸橼酸氯米芬/人绝经期促性腺激素刺激进行体外受精后，卵巢反应的程度是否会损害卵母细胞或胚胎质量。
卵母细胞数量增加与受精率降低（r = -0.36，P < 0.001）和雌二醇/卵泡比率降低（r = -0.443，P < 0.001）相关，尽管所产生胚胎的质量未受影响。尽管受精率降低，但较高的卵母细胞数量产生了更多可用于立即移植或冷冻保存的健康胚胎（r = 0.70，P < 0.001）。各组间的着床率没有差异，也未确定预测变量。
这些结果表明，子宫内膜容受性和着床并未受到雌二醇水平升高的不利影响。与获取大量卵母细胞相关的卵母细胞质量下降似乎被更多可用于立即移植和冷冻保存的胚胎所抵消。
