Oguzlu Hale, Baldelli Alberto, Mohammadi Xanyar, Kong Albert, Bacca Mattia, Pratap-Singh Anubhav
Faculty of Dentistry, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver V6T 1Z4, Canada.
Sustainable Functional Biomaterials Laboratory, Department of Wood Science, The University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
ACS Omega. 2024 Aug 1;9(33):35634-35644. doi: 10.1021/acsomega.4c03787. eCollection 2024 Aug 20.
Cold plasma treatment is commonly used for sterilization. However, another potential of cold plasma treatment is surface modification. To date, several efforts have been directed toward investigating the effect of cold plasma treatment in modifying the surfaces of films. Here, the impact of suspension properties and parameters of cold plasma treatment on the changes of surfaces of monodisperse polymeric microparticles is tested. The plasma treatment did not touch the surface chemistry of the monodisperse polymeric microparticles. The concentration of suspensions of 1 mg/mL was determined to relate to a stronger effect of the plasma treatment on the roughness of the microparticles. Microparticles with an average diameter of 20 μm show a roughness increase with the plasma treatment time. However, a plasma treatment time longer than 15 min damages the microparticles, as observed in particles with an average diameter of 20 and 50 μm. We finally prototyped monodisperse microparticles to deliver drugs to the nasal mucosa by studying the effect of roughness in their (undesired) self-adhesion and (desired) adhesion with tissue. A moderate roughness, with an average peak-to-valley distance of 500 nm, appears to be the most effective in reducing the detachment forces with nasal tissue by up to 5 mN.
冷等离子体处理通常用于灭菌。然而，冷等离子体处理的另一个潜在用途是表面改性。迄今为止，已经进行了多项努力来研究冷等离子体处理对薄膜表面改性的影响。在此，测试了悬浮液性质和冷等离子体处理参数对单分散聚合物微粒表面变化的影响。等离子体处理并未触及单分散聚合物微粒的表面化学性质。确定1 mg/mL的悬浮液浓度与等离子体处理对微粒粗糙度的更强影响有关。平均直径为20μm的微粒随着等离子体处理时间的增加粗糙度增大。然而，如在平均直径为20μm和50μm的微粒中观察到的那样，等离子体处理时间超过15分钟会损坏微粒。通过研究粗糙度对其（不希望的）自粘附和（期望的）与组织粘附的影响，我们最终制作了用于将药物递送至鼻粘膜的单分散微粒原型。平均峰谷距离为500 nm的适度粗糙度似乎在将与鼻组织的分离力降低多达5 mN方面最为有效。
