Faculty of Land and Food Systems, The University of British Columbia, BC, Canada.
Mechanical Power Engineering Department, Zagazig University, Zagazig 44519, Egypt; Smart Engineering Systems Research Center (SESC), Nile University, Giza 12588, Egypt.
Drug Discov Today. 2022 Aug;27(8):2300-2308. doi: 10.1016/j.drudis.2022.04.012. Epub 2022 Apr 19.
In this review, we present the potential of nasal dry powders to deliver stable bioactive compounds and their manufacture using spray-drying (SD) techniques to achieve encapsulation. We also review currently approved and experimental excipients used for powder manufacturing for specific target drugs. Polymers, sugars, and amino acids are recommended for specific actions, such as mucoadhesive interactions, to increase residence time on the nasal mucosa; for example, high-molecular weight polymers, such as hydroxypropyl methylcellulose, or mannitol, which protect the bioactive compounds, increase their stability, and enhance drug absorption in the nasal mucosa; and leucine, which promotes particle formation and improves aerosol performance.
在这篇综述中，我们介绍了鼻腔干粉制剂递送稳定生物活性化合物的潜力及其使用喷雾干燥（SD）技术进行封装的制造方法。我们还审查了目前批准和实验性辅料用于特定靶标药物的粉末制造。推荐使用聚合物、糖和氨基酸等辅料，以实现特定作用，如增加在鼻黏膜上的停留时间的黏膜黏附相互作用；例如，高分子量聚合物，如羟丙基甲基纤维素或甘露醇，可保护生物活性化合物，提高其稳定性，并增强药物在鼻黏膜中的吸收；亮氨酸可促进颗粒形成并改善气雾剂性能。
