Nalina Kumari Chellathurai Burnice, N Ambalavanan, Shanmugam Rajeshkumar, Mahendra Jaideep, Sudhakar Uma
Department of Periodontology, Meenakshi Ammal Dental College and Hospital, Meenakshi Academy of Higher Education and Research, Chennai, IND.
Nanobiomedicine Laboratory, Centre for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, IND.
Cureus. 2024 Jul 26;16(7):e65409. doi: 10.7759/cureus.65409. eCollection 2024 Jul.
The tropical plant acerola of the genus includes shrubs and trees with fruit that is high in nutrients and bioactive chemicals. Acerola stands out due to its exceptionally high ascorbic acid content, ranging from 1500 to 4500 mg/100 g. Vitamin C intake greatly influences gingival health. The addition of nanoparticles along with vitamin C-rich acerola exhibits high antioxidant and anti-inflammatory properties, thereby positively improving gingival health.
The antioxidant and anti-inflammatory properties of aqueous extracts of the acerola plant () were assessed. Silver nanoparticles (AgNPs) and copper oxide nanoparticles (CuONPs) were synthesized using the aqueous extract of acerola cherry gel by the phytogenic fabrication method. The antioxidant potential of silver and copper nanoparticles was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydrogen peroxide, ferric reducing antioxidant power (FRAP), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and nitric oxide scavenging activities.
Increasing concentrations of nanoparticles showed an increase in scavenging activity. Overall, CuONPs and AgNPs exhibited remarkable radical quenching efficacies. The anti-inflammatory effectiveness of CuONPs and AgNPs was monitored, showing suppression of protein denaturation as demonstrated by bovine serum albumin (BSA), egg albumin (EA), and membrane stabilization assays. The results revealed that increasing the doses of CuONPs and AgNPs had a positive impact on the anti-inflammatory activity of the nanoparticles.
The present study revealed that both nanoparticles provided better antioxidant and anti-inflammatory activities. This study also elaborates on the pharmacological potential of both nanoparticles, which could be further explored for application in all healthcare sectors.
番荔枝属的热带植物针叶樱桃包括灌木和乔木，其果实富含营养和生物活性化学物质。针叶樱桃因其极高的抗坏血酸含量（1500至4500毫克/100克）而脱颖而出。维生素C的摄入量对牙龈健康有很大影响。纳米颗粒与富含维生素C的针叶樱桃一起添加具有高抗氧化和抗炎特性，从而对牙龈健康有积极改善作用。
评估了针叶樱桃植物水提取物的抗氧化和抗炎特性。采用植物源制备方法，利用针叶樱桃凝胶水提取物合成了银纳米颗粒（AgNPs）和氧化铜纳米颗粒（CuONPs）。使用2,2-二苯基-1-苦基肼（DPPH）、过氧化氢、铁还原抗氧化能力（FRAP）、2,2'-偶氮双（3-乙基苯并噻唑啉-6-磺酸）（ABTS）和一氧化氮清除活性评估银和铜纳米颗粒的抗氧化潜力。
纳米颗粒浓度增加，清除活性增强。总体而言，CuONPs和AgNPs表现出显著的自由基淬灭效果。监测了CuONPs和AgNPs的抗炎效果，通过牛血清白蛋白（BSA）、蛋清蛋白（EA）和膜稳定性测定证明其对蛋白质变性有抑制作用。结果表明，增加CuONPs和AgNPs的剂量对纳米颗粒的抗炎活性有积极影响。
本研究表明，两种纳米颗粒均具有更好的抗氧化和抗炎活性。本研究还阐述了两种纳米颗粒的药理潜力，可在所有医疗保健领域进一步探索其应用。
