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分娩期间胰岛素意外注入硬膜外腔。

Unintentional Infusion of Insulin Into the Epidural Space During Labor.

作者信息

Neves Sara S, Almeida Joana

机构信息

Department of Anesthesiology, Centro Hospitalar Universitário de Santo António, Porto, PRT.

出版信息

Cureus. 2024 Jul 25;16(7):e65371. doi: 10.7759/cureus.65371. eCollection 2024 Jul.

DOI:10.7759/cureus.65371
PMID:39184592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11344581/
Abstract

Inadvertent injection of drugs into the epidural space has a potential for serious morbidity and is probably underestimated and underreported. A 39-year-old female with no medical history presented for delivery. An epidural catheter was requested and correctly placed. Continuous epidural infusion was chosen for labor analgesia. Six hours after the parturient complained about inefficient analgesia, a syringe swap with insulin was identified. Despite the risk of possibly neurotoxic preservatives in the insulin formulation, no neurological sequelae were observed. This case highlights the issue of wrong-route drug administration and the urgent need to adopt route-specific connections.

摘要

意外将药物注入硬膜外腔有导致严重发病的可能性,且可能被低估和漏报。一名无病史的39岁女性前来分娩。应要求置入了硬膜外导管且放置正确。选择持续硬膜外输注用于分娩镇痛。产妇抱怨镇痛效果不佳6小时后,发现与胰岛素的注射器发生了交换。尽管胰岛素制剂中可能存在具有神经毒性的防腐剂,但未观察到神经后遗症。该病例凸显了错误给药途径的问题以及采用特定途径连接的迫切需求。

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本文引用的文献

1
Inadvertent Epidural and Intravenous Line Swap: A Case Report.意外的硬膜外和静脉输液管交换:一例报告
Cureus. 2023 Mar 26;15(3):e36698. doi: 10.7759/cureus.36698. eCollection 2023 Mar.
2
[Inadvertent epidural ampicillin administration during labor: case report].[分娩期间意外硬膜外给予氨苄西林:病例报告]
Braz J Anesthesiol. 2020 Jan-Feb;70(1):63-65. doi: 10.1016/j.bjan.2019.12.004. Epub 2020 Feb 19.
3
[Inadvertent epidural infusion of paracetamol].[对乙酰氨基酚意外硬膜外输注]
Rev Esp Anestesiol Reanim. 2014 Oct;61(8):457-9. doi: 10.1016/j.redar.2013.08.005. Epub 2013 Dec 10.
4
Inadvertent epidural injection of drugs for intravenous use. A review.意外硬膜外注射静脉用药物。综述。
Acta Anaesthesiol Belg. 2012;63(2):75-9.
5
Safer administration of insulin: summary of a safety report from the National Patient Safety Agency.胰岛素的更安全给药:国家患者安全机构安全报告摘要
BMJ. 2010 Oct 13;341:c5269. doi: 10.1136/bmj.c5269.
6
Inadvertent epidural administration of insulin.胰岛素意外硬膜外给药。
Anaesthesia. 2007 Jun;62(6):621-3. doi: 10.1111/j.1365-2044.2007.04996.x.
7
Inadvertent administration of magnesium sulfate through the epidural catheter: report and analysis of a drug error.
Int J Obstet Anesth. 2006 Jan;15(1):63-7. doi: 10.1016/j.ijoa.2005.06.009. Epub 2005 Oct 26.
8
Avoiding inadvertent epidural injection of drugs intended for non-epidural use.避免将用于非硬膜外的药物误注入硬膜外。
Anaesth Intensive Care. 2003 Feb;31(1):44-9. doi: 10.1177/0310057X0303100108.
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Anaesth Intensive Care. 1993 Oct;21(5):596-601. doi: 10.1177/0310057X9302100517.
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Constant intravenous insulin infusion during labor and delivery in diabetes mellitus.
Diabetes Care. 1982 Jan-Feb;5(1):6-10. doi: 10.2337/diacare.5.1.6.