Dao Kevin T, Dhillon Amrit, Uddin Syed Saad, Garcia-Corella Jose, Inga Jaco Elias, Zahid Mahum, Sharma Rupam, Lai Hobart
Internal Medicine, University of California, Los Angeles (UCLA) - Kern Medical, Bakersfield, USA.
Cureus. 2024 Jul 25;16(7):e65364. doi: 10.7759/cureus.65364. eCollection 2024 Jul.
Shigella flexneri (S. flexneri) is a facultatively anaerobic gram-negative bacterium that is a member of Enterobacteriaceae. The bacterium has been known to cause mild symptoms, such as diarrhea, to more severe diseases such as hemorrhagic colitis. Fortunately, such instances of severe diseases are rare. Nevertheless, even though S. flexneri is a more benign bacterium of the Shigella genus when compared to Shigella dysenteriae, this doesn't mean that it should be neglected. In fact, the ability of this microorganism to cause inflammation of the colon or colitis and disrupt tissue architecture can allow other organisms that would otherwise be benign to cause severe complications, hence allowing said organisms to be opportunistic. Here, we would like to present a case of S. flexneri colitis resulting in bacillus bacteremia and eventually causing an inappropriate physiological host response leading to hypotension, systematic organ failure, etc., also known as septic shock. The pathogenesis and treatment of this patient will also be discussed.
福氏志贺菌是一种兼性厌氧的革兰氏阴性菌，属于肠杆菌科。已知该细菌可引起轻度症状，如腹泻，也可导致更严重的疾病，如出血性结肠炎。幸运的是，这种严重疾病的情况很少见。然而，尽管与痢疾志贺菌相比，福氏志贺菌是志贺菌属中一种相对温和的细菌，但这并不意味着它可以被忽视。事实上，这种微生物引起结肠炎症或结肠炎以及破坏组织结构的能力，会使其他原本无害的生物体引发严重并发症，从而使这些生物体具有机会致病性。在此，我们将呈现一例福氏志贺菌结肠炎导致芽孢杆菌血症，并最终引起不适当的生理宿主反应，导致低血压、全身器官衰竭等，即感染性休克的病例。还将讨论该患者的发病机制和治疗方法。
