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成人起病的急性弛缓性脊髓炎:一例报告

Adult Onset Acute Flaccid Myelitis: A Case Report.

作者信息

Peeran Ahmad, Fallatah Sameeha, Akour Ameera, Alanazi Ali

机构信息

Neurology, King Abdulaziz Medical City Riyadh, Riyadh, SAU.

Radiology/Neuroradiology, King Abdulaziz Medical City Riyadh, Riyadh, SAU.

出版信息

Cureus. 2024 Jul 24;16(7):e65294. doi: 10.7759/cureus.65294. eCollection 2024 Jul.

DOI:10.7759/cureus.65294
PMID:39184722
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11343482/
Abstract

We report a 23-year-old male who presented with acute dysarthria, dysphagia, and quadriparesis. These symptoms were preceded by fever and headache. His neurological symptoms were progressive and rendered him quadriplegic over three weeks. Extensive workup for infectious, inflammatory, and neoplastic etiologies was negative; however, the clinical course and magnetic resonance imaging of the brain and spinal cord were consistent with the United States Centres for Disease Control and Prevention (CDC) criteria of acute flaccid myelitis. The patient had various lines of therapy, including antimicrobial agents, intravenous immunoglobulin, plasma exchange, and corticosteroids but he was discharged with significant disability. Despite the increasing number of reported cases worldwide, many aspects of this condition remain unknown including its pathophysiology and optimal treatment regimen. In this case report, we shed light on this clinical entity to increase awareness among practitioners worldwide.

摘要

我们报告了一名23岁男性,他出现急性构音障碍、吞咽困难和四肢轻瘫。这些症状之前有发热和头痛。他的神经症状呈进行性发展,在三周内导致他四肢瘫痪。针对感染、炎症和肿瘤病因的广泛检查均为阴性;然而,脑部和脊髓的临床病程及磁共振成像符合美国疾病控制与预防中心(CDC)的急性弛缓性脊髓炎标准。该患者接受了多种治疗,包括抗菌药物、静脉注射免疫球蛋白、血浆置换和皮质类固醇,但出院时仍有严重残疾。尽管全球报告的病例数量不断增加,但这种疾病的许多方面仍然未知,包括其病理生理学和最佳治疗方案。在本病例报告中,我们阐明了这一临床实体,以提高全球从业者的认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a2/11343482/84d6c7367b27/cureus-0016-00000065294-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a2/11343482/9dc361d4c722/cureus-0016-00000065294-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a2/11343482/eb5408891437/cureus-0016-00000065294-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a2/11343482/84d6c7367b27/cureus-0016-00000065294-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a2/11343482/9dc361d4c722/cureus-0016-00000065294-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a2/11343482/eb5408891437/cureus-0016-00000065294-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a2/11343482/84d6c7367b27/cureus-0016-00000065294-i03.jpg

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本文引用的文献

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Monitoring of Enterovirus D68 Outbreak in Israel by a Parallel Clinical and Wastewater Based Surveillance.以色列通过平行临床和污水监测对肠道病毒 D68 暴发的监测。
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Acute Flaccid Myelitis.急性弛缓性脊髓炎。
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J Infect Dis. 2017 Dec 5;216(10):1245-1253. doi: 10.1093/infdis/jix468.
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A mouse model of paralytic myelitis caused by enterovirus D68.由肠道病毒D68引起的麻痹性脊髓炎小鼠模型。
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Acute Flaccid Myelitis in the United States, August-December 2014: Results of Nationwide Surveillance.2014年8月至12月美国急性弛缓性脊髓炎:全国监测结果
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