Hamed Nazim F, Alahmad Al Sakran Wessal M, Serhan Ashraf I, Eladwy Mohamed Farahat Mohamed, Elshahhat Tamer Mohamed Mohamed, Abu Lebeh Ahmad Salem, Elsharif Sakinah Mohammed, Alshaqha Hajar K
General Pediatrics, Maternity and Children Hospital, Tabuk, Tabuk, SAU.
Pediatrics, Security Force Hospital, Dammam, Dammam, SAU.
Cureus. 2024 Jul 24;16(7):e65264. doi: 10.7759/cureus.65264. eCollection 2024 Jul.
This study aims to comprehensively investigate the association between childhood asthma and gastroesophageal reflux disease (GERD) in children. A thorough search of pertinent databases was done in order to find studies that satisfied the requirements for inclusion. A thorough search of PubMed, Web of Science, SCOPUS, and Science Direct was conducted to find pertinent literature. Twelve studies, including a total of 176,678 patients - 91,447 (51.8%) of them were males - were included in our data. The prevalence of GERD in asthmatic children ranged from 0.7% to 65.3%, with a total prevalence of 3317 (3.6%). The included studies documented that GERD increases the chance of asthma, while asthma raises the risk of GERD. Obesity in asthmatic patients was an independent risk factor for the incidence of GERD. Controlling asthma is significantly impacted by comorbidities like obesity and GRED. The findings of our comprehensive review point to a possible link between juvenile patients with asthma who are referred to secondary and tertiary care facilities and having GERD. Nevertheless, the evidence for this link is weak in a number of situations. Lack of longitudinal research establishing the proper temporal sequence, studies indicating no severity-response relationship, and insufficient data showing a treatment-response relationship all contribute to the uncertainty around the nature and direction of the association. Our findings highlight the need for additional epidemiologic research to investigate the connection between GERD and asthma, including long-term follow-up.
本研究旨在全面调查儿童期哮喘与儿童胃食管反流病（GERD）之间的关联。为了找到符合纳入要求的研究，我们对相关数据库进行了全面检索。对PubMed、科学网、Scopus和科学Direct进行了全面检索以查找相关文献。我们的数据纳入了12项研究，共计176,678名患者，其中91,447名（51.8%）为男性。哮喘儿童中GERD的患病率在0.7%至65.3%之间，总患病率为3317例（3.6%）。纳入的研究表明，GERD会增加患哮喘的几率，而哮喘会增加患GERD的风险。哮喘患者的肥胖是GERD发病的独立危险因素。肥胖和胃食管反流病等合并症对哮喘的控制有显著影响。我们综合评价的结果表明，转诊至二级和三级医疗机构的青少年哮喘患者与患有GERD之间可能存在联系。然而，在许多情况下，这种联系的证据很薄弱。缺乏确定正确时间顺序的纵向研究、表明无严重程度-反应关系的研究以及显示治疗-反应关系的数据不足，都导致了这种关联的性质和方向存在不确定性。我们的研究结果强调需要进行更多的流行病学研究来调查GERD与哮喘之间的联系，包括长期随访。
