Jaimchariyatam Nattapong, Wongtim Somkiat, Udompanich Visit, Sittipunt Chanchai, Kawkitinarong Kamon, Chaiyakul Sataporn, Gonlachanvit Sutep
Division of Pulmonary and Critical Care, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Med Assoc Thai. 2011 Jun;94(6):671-8.
Asthma is a chronic inflammatory disorder of airways and associated with airway hyperresponsiveness and reversible bronchoconstriction. Gastroesophageal reflux disease (GERD) is a disorder caused by the reflux of gastric content up into the esophagus. It has been proposed that GERD is one of the exacerbating factors in the patients with poor controlled asthma.
Determine the prevalence of GERD in asthmatic patients and the association between GERD and the level of asthma control in Thailand.
A cross-sectional descriptive study was conducted in 56 asthmatic patients at the King Chulalongkorn Memorial Hospital. They were performed twenty-four-hour esophageal pH monitoring.
The prevalence of GERD in Thai asthmatic patients was 37.50%. Fifteen of 21 patients (71.43%) with GERD experienced reflux symptoms. The sensitivity specificity, positive predictive value and negative predictive value of reflux symptoms for diagnosis GERD were 71.43%, 77.14%, 65.22% and 81.82%, respectively. The prevalence of GERD was higher in uncontrolled asthmatic patients than partly controlled and controlled subjects. Among uncontrolled asthma, the prevalence of GERD was higher than those without GERD (57.17% and 25.72%, respectively, p = 0.028). Asthma Control Test (ACT) score of less than twenty (poor controlled asthma) was higher in the asthmatic patients with GERD than those without GERD (80.95% and 48.57%, respectively, p = 0.024).
The authors concluded that the prevalence of GERD in Thai asthmatic patients was 37.50%. There was significant association between GERD and the level of asthma control.
哮喘是一种气道慢性炎症性疾病，与气道高反应性和可逆性支气管收缩相关。胃食管反流病（GERD）是一种由胃内容物反流至食管引起的疾病。有人提出，GERD是哮喘控制不佳患者的加重因素之一。
确定泰国哮喘患者中GERD的患病率以及GERD与哮喘控制水平之间的关联。
在朱拉隆功国王纪念医院对56例哮喘患者进行了一项横断面描述性研究。对他们进行了24小时食管pH监测。
泰国哮喘患者中GERD的患病率为37.50%。21例GERD患者中有15例（71.43%）出现反流症状。反流症状诊断GERD的敏感性、特异性、阳性预测值和阴性预测值分别为71.43%、77.14%、65.22%和81.82%。未控制的哮喘患者中GERD的患病率高于部分控制和已控制的患者。在未控制的哮喘患者中，GERD的患病率高于无GERD的患者（分别为57.17%和25.72%，p = 0.028）。GERD哮喘患者中哮喘控制测试（ACT）得分低于20（哮喘控制不佳）的比例高于无GERD的患者（分别为80.95%和48.57%，p = 0.024）。
作者得出结论，泰国哮喘患者中GERD的患病率为37.50%。GERD与哮喘控制水平之间存在显著关联。
