阿立哌唑剂量增加后出现动眼危象：一例报告
Oculogyric Crisis Following Dosage Increase of Aripiprazole: A Case Report.
作者信息
Malik Nikhale, Othman Sally, Tiwari Apoorv, Mantravadi Sushmita, Salari Syeda, Dabaja Abed, Kambhatla Sujata
机构信息
Internal Medicine, Garden City Hospital, Garden City, USA.
出版信息
Cureus. 2024 Jul 24;16(7):e65295. doi: 10.7759/cureus.65295. eCollection 2024 Jul.
Oculogyric crisis (OGC) is a form of acute dystonia with involuntary conjugated ocular gaze in a fixed position. Common causes include metabolic disorders and medications, primarily typical antipsychotics. A 24-year-old male with a history of persistent depressive disorder and possible bipolar disorder was admitted to the psychiatric unit due to suicidal ideation. He was started on aripiprazole 5 mg and subsequently increased to 10 mg due to uncontrolled mood disorder. The patient subsequently developed OGC, which resolved with benztropine and diphenhydramine. This case report highlights aripiprazole-induced OGC and prompt management with benztropine and first-generation antihistamines.
动眼危象（OGC）是一种急性肌张力障碍形式，表现为双眼不自主地固定凝视在某一位置。常见病因包括代谢紊乱和药物，主要是典型抗精神病药物。一名有持续性抑郁症病史且可能患有双相情感障碍的24岁男性因自杀观念入住精神科病房。他开始服用阿立哌唑5毫克，随后因情绪障碍控制不佳而增至10毫克。该患者随后出现了动眼危象，使用苯海索和苯海拉明后症状得到缓解。本病例报告强调了阿立哌唑诱发的动眼危象以及使用苯海索和第一代抗组胺药的及时治疗。
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