一名已部署的军事人员在预防性服用甲氟喹后出现严重神经精神反应。
Severe neuropsychiatric reaction in a deployed military member after prophylactic mefloquine.
作者信息
Peterson Alan L, Seegmiller Robert A, Schindler Libby S
机构信息
Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX 78229, USA.
出版信息
Case Rep Psychiatry. 2011;2011:350417. doi: 10.1155/2011/350417. Epub 2011 Sep 8.
Abstract
Recent studies of military personnel who have deployed to Iraq and Afghanistan have reported a number of combat-related psychiatric disorders such as posttraumatic stress disorder, depression, and traumatic brain injury. This case report involves a 27-year-old male active-duty US military service member who developed severe depression, psychotic hallucinations, and neuropsychological sequelae following the prophylactic use of the antimalarial medication mefloquine hydrochloride. The patient had a recent history of depression and was taking antidepressant medications at the time of his deployment to the Middle East. Psychiatrists and other health care providers should be aware of the possible neuropsychiatric side effects of mefloquine in deployed military personnel and should consider the use of other medications for malaria prophylaxis in those individuals who may be at increased risk for side effects.
摘要
近期对曾部署到伊拉克和阿富汗的军事人员的研究报告了一些与战斗相关的精神疾病，如创伤后应激障碍、抑郁症和创伤性脑损伤。本病例报告涉及一名27岁的美国现役男性军人，他在预防性使用抗疟药物盐酸甲氟喹后出现了严重的抑郁症、精神病性幻觉和神经心理学后遗症。该患者近期有抑郁症病史，在被部署到中东时正在服用抗抑郁药物。精神科医生和其他医疗服务提供者应意识到甲氟喹在被部署的军事人员中可能产生的神经精神副作用，并应考虑在那些可能有更高副作用风险的个体中使用其他药物进行疟疾预防。
相似文献
1
Severe neuropsychiatric reaction in a deployed military member after prophylactic mefloquine.一名已部署的军事人员在预防性服用甲氟喹后出现严重神经精神反应。
Case Rep Psychiatry. 2011;2011:350417. doi: 10.1155/2011/350417. Epub 2011 Sep 8.
2
Combat duty in Iraq and Afghanistan, mental health problems and barriers to care.在伊拉克和阿富汗的战斗任务、心理健康问题及护理障碍。
US Army Med Dep J. 2008 Jul-Sep:7-17.
3
Deployment of personnel to military operations: impact on mental health and social functioning.人员部署到军事行动中：对心理健康和社会功能的影响。
Campbell Syst Rev. 2018 Jun 1;14(1):1-127. doi: 10.4073/csr.2018.6. eCollection 2018.
4
Mefloquine prescriptions in the presence of contraindications: prevalence among US military personnel deployed to Afghanistan, 2007.有禁忌症时开具甲氟喹处方：2007 年驻阿富汗美军中的流行情况。
Pharmacoepidemiol Drug Saf. 2010 Feb;19(2):206-10. doi: 10.1002/pds.1879.
5
Psychiatric Aeromedical Evacuations of Deployed Active Duty U.S. Military Personnel During Operations Enduring Freedom, Iraqi Freedom, and New Dawn.在“持久自由行动”“伊拉克自由行动”和“新黎明行动”期间，对部署的美国现役军事人员进行的精神科航空医疗后送
Mil Med. 2018 Nov 1;183(11-12):e649-e658. doi: 10.1093/milmed/usy188.
6
[Mood disorder after malaria prophylaxis with mefloquine (two case reports)].[使用甲氟喹预防疟疾后出现的情绪障碍（两例报告）]
Encephale. 2011 Oct;37(5):393-6. doi: 10.1016/j.encep.2011.01.013. Epub 2011 Mar 25.
7
Associations between Use of Antimalarial Medications and Health among U.S. Veterans of the Wars in Iraq and Afghanistan.美国伊拉克和阿富汗战争老兵中使用抗疟药物与健康之间的关联。
Am J Trop Med Hyg. 2018 Sep;99(3):638-648. doi: 10.4269/ajtmh.18-0107. Epub 2018 Jun 21.
8
Prevalence of contraindications to mefloquine use among USA military personnel deployed to Afghanistan.部署到阿富汗的美国军事人员中使用甲氟喹的禁忌证患病率。
Malar J. 2008 Feb 11;7:30. doi: 10.1186/1475-2875-7-30.
9
Acute Assessment of Traumatic Brain Injury and Post-Traumatic Stress After Exposure to a Deployment-Related Explosive Blast.暴露于与部署相关的爆炸冲击后创伤性脑损伤和创伤后应激的急性评估
Mil Med. 2018 Nov 1;183(11-12):e555-e563. doi: 10.1093/milmed/usy100.
10
Mental health problems, use of mental health services, and attrition from military service after returning from deployment to Iraq or Afghanistan.从伊拉克或阿富汗部署归来后的心理健康问题、心理健康服务的使用情况以及服役人员流失情况。
JAMA. 2006 Mar 1;295(9):1023-32. doi: 10.1001/jama.295.9.1023.
引用本文的文献
1
Oculogyric Crisis Following Dosage Increase of Aripiprazole: A Case Report.阿立哌唑剂量增加后出现动眼危象：一例报告
Cureus. 2024 Jul 24;16(7):e65295. doi: 10.7759/cureus.65295. eCollection 2024 Jul.
2
Associations between Use of Antimalarial Medications and Health among U.S. Veterans of the Wars in Iraq and Afghanistan.美国伊拉克和阿富汗战争老兵中使用抗疟药物与健康之间的关联。
Am J Trop Med Hyg. 2018 Sep;99(3):638-648. doi: 10.4269/ajtmh.18-0107. Epub 2018 Jun 21.
3
Antimalarial drugs and the prevalence of mental and neurological manifestations: A systematic review and meta-analysis.抗疟药物与精神和神经表现的患病率：一项系统评价和荟萃分析。
Wellcome Open Res. 2017 Jun 2;2:13. doi: 10.12688/wellcomeopenres.10658.2. eCollection 2017.
4
Neuropsychiatric Outcomes After Mefloquine Exposure Among U.S. Military Service Members.美国军人服用甲氟喹后的神经精神结局
Am J Trop Med Hyg. 2017 Jan 11;96(1):159-166. doi: 10.4269/ajtmh.16-0390. Epub 2016 Nov 14.
5
Identification of a Syndrome Class of Neuropsychiatric Adverse Reactions to Mefloquine from Latent Class Modeling of FDA Adverse Event Reporting System Data.基于美国食品药品监督管理局不良事件报告系统数据的潜在类别模型，识别甲氟喹神经精神不良反应的一种综合征类别。
Drugs R D. 2017 Mar;17(1):199-210. doi: 10.1007/s40268-016-0167-3.
6
Psychiatric effects of malaria and anti-malarial drugs: historical and modern perspectives.疟疾和抗疟药物的精神影响：历史与现代视角
Malar J. 2016 Jun 22;15:332. doi: 10.1186/s12936-016-1391-6.
7
Behavioral effects of mefloquine in tail suspension and light/dark tests.甲氟喹在悬尾试验和明暗箱试验中的行为学效应。
Springerplus. 2015 Nov 17;4:702. doi: 10.1186/s40064-015-1483-8. eCollection 2015.
8
Rational Risk-Benefit Decision-Making in the Setting of Military Mefloquine Policy.军事甲氟喹政策背景下的合理风险效益决策
J Parasitol Res. 2015;2015:260106. doi: 10.1155/2015/260106. Epub 2015 Oct 22.
9
Complex Membrane Channel Blockade: A Unifying Hypothesis for the Prodromal and Acute Neuropsychiatric Sequelae Resulting from Exposure to the Antimalarial Drug Mefloquine.复杂膜通道阻滞：暴露于抗疟药甲氟喹导致的前驱期和急性神经精神后遗症的统一假说。
J Parasitol Res. 2015;2015:368064. doi: 10.1155/2015/368064. Epub 2015 Oct 20.
10
Mefloquine in the nucleus accumbens promotes social avoidance and anxiety-like behavior in mice.伏隔核中的甲氟喹促进小鼠的社交回避和焦虑样行为。
Neuropharmacology. 2016 Feb;101:351-7. doi: 10.1016/j.neuropharm.2015.10.013. Epub 2015 Oct 22.
本文引用的文献
1
Effects of low-level exposure to sarin and cyclosarin during the 1991 Gulf War on brain function and brain structure in US veterans.1991 年海湾战争中低水平暴露于沙林和梭曼对美国退伍军人的大脑功能和结构的影响。
Neurotoxicology. 2010 Sep;31(5):493-501. doi: 10.1016/j.neuro.2010.05.006. Epub 2010 May 24.
2
What are the consequences of deployment to Iraq and Afghanistan on the mental health of the UK armed forces? A cohort study.部署到伊拉克和阿富汗对英国武装部队心理健康的后果是什么？一项队列研究。
Lancet. 2010 May 22;375(9728):1783-97. doi: 10.1016/S0140-6736(10)60672-1. Epub 2010 May 12.
3
Mefloquine prescriptions in the presence of contraindications: prevalence among US military personnel deployed to Afghanistan, 2007.有禁忌症时开具甲氟喹处方：2007 年驻阿富汗美军中的流行情况。
Pharmacoepidemiol Drug Saf. 2010 Feb;19(2):206-10. doi: 10.1002/pds.1879.
4
Characterizing mineral dusts and other aerosols from the Middle East--Part 1: ambient sampling.表征来自中东的矿物粉尘及其他气溶胶——第1部分：环境采样。
Inhal Toxicol. 2009 Feb;21(4):297-326. doi: 10.1080/08958370802464273.
5
Deployment-related stress and trauma in Dutch soldiers returning from Iraq. Prospective study.从伊拉克返回的荷兰士兵中与部署相关的压力和创伤。前瞻性研究。
Br J Psychiatry. 2007 Aug;191:140-5. doi: 10.1192/bjp.bp.106.034884.
6
Demographics of and diagnoses in Operation Enduring Freedom and Operation Iraqi Freedom personnel who were psychiatrically evacuated from the theater of operations.从作战区域被精神科后送的“持久自由行动”和“伊拉克自由行动”人员的人口统计学特征及诊断情况。
Gen Hosp Psychiatry. 2006 Jul-Aug;28(4):352-6. doi: 10.1016/j.genhosppsych.2006.04.006.
7
Mental health problems, use of mental health services, and attrition from military service after returning from deployment to Iraq or Afghanistan.从伊拉克或阿富汗部署归来后的心理健康问题、心理健康服务的使用情况以及服役人员流失情况。
JAMA. 2006 Mar 1;295(9):1023-32. doi: 10.1001/jama.295.9.1023.
8
Symptoms and medical conditions in Australian veterans of the 1991 Gulf War: relation to immunisations and other Gulf War exposures.1991年海湾战争澳大利亚退伍军人的症状与医疗状况：与免疫接种及其他海湾战争接触因素的关系
Occup Environ Med. 2004 Dec;61(12):1006-13. doi: 10.1136/oem.2003.009258.
9
Neuropsychiatric events during prophylactic use of mefloquine before travelling.旅行前预防性使用甲氟喹期间的神经精神事件。
Eur J Clin Pharmacol. 2002 Sep;58(6):441-5. doi: 10.1007/s00228-002-0492-z. Epub 2002 Jul 27.
10
Mefloquine-induced paranoid psychosis and subsequent major depression in a 25-year-old student.
Pharmacopsychiatry. 2002 Sep;35(5):200-2. doi: 10.1055/s-2002-34114.
Zotero 插件