Itoh J, Nakagawa H, Sasaki H, Takahashi T
Gan To Kagaku Ryoho. 1985 Feb;12(2):258-64.
The chemotherapeutic and ischemic effects of a fibrin clot containing mitomycin-C were observed on a model of primary hepatoma using VX-2 carcinoma inoculated in to the subcapsule of the liver of rabbits. The results of antitumor effect suppression of pulmonary and intrahepatic metastases and survival time using the fibrin clot containing mitomycin-C were better than with other treatments, namely a one-shot infusion of MMC or embolization with fibrin clot only. A synergistic antitumor effect was obtained using embolization with the fibrin clot incorporating mitomycin-C. Using direct subcapsular inoculation with a VX-2 carcinoma block a solitary hepatic tumor was obtained which was hypervascular and resembled human primary hepatoma. These results suggested that a fibrin clot containing an anticancer drug is safe a and effective modality for hepatic or other arterial embolization therapies.
在兔肝包膜下接种VX-2癌建立的原发性肝癌模型上，观察了含丝裂霉素-C的纤维蛋白凝块的化疗和缺血效应。使用含丝裂霉素-C的纤维蛋白凝块在抑制肺和肝内转移以及延长生存时间方面的抗肿瘤效果，优于其他治疗方法，即单次输注丝裂霉素或仅用纤维蛋白凝块栓塞。含丝裂霉素-C的纤维蛋白凝块栓塞可产生协同抗肿瘤作用。通过在肝包膜下直接接种VX-2癌块，获得了一个高血供的孤立性肝肿瘤，其类似于人类原发性肝癌。这些结果表明，含抗癌药物的纤维蛋白凝块对于肝或其他动脉栓塞治疗是一种安全有效的方式。
