Itoh J, Nakagawa H, Sasaki H, Takahashi T
Gan To Kagaku Ryoho. 1985 Feb;12(2):250-7.
A new embolus consisting of a fibrin clot containing an anticancer drug (mitomycin-C) was devised. An experimental study was then performed using the new embolus in dogs and several interesting characteristics were observed. The fibrin clot containing mitomycin-C was in a fluid from when infused and its action as an embolus did not occur until it reached a target artery. The fibrin clot containing mitomycin-C formed a mold within of the arteries in which it was embolized and was soluble with urokinase during a ten-hour period. The release of mitomycin-C from the fibrin clot was sustained over sixty hours. The intraarterial occlusion formed by fibrin clot was temporary, and recanalization was observed over forty-eight by hours by both angiography and pathological examination.
设计了一种由含有抗癌药物（丝裂霉素 - C）的纤维蛋白凝块组成的新型栓子。随后在犬身上使用这种新型栓子进行了一项实验研究，并观察到了一些有趣的特性。含有丝裂霉素 - C的纤维蛋白凝块在注入时呈流体状，直到到达靶动脉时才发挥栓子的作用。含有丝裂霉素 - C的纤维蛋白凝块在其栓塞的动脉内形成一个模子，并且在10小时内可被尿激酶溶解。丝裂霉素 - C从纤维蛋白凝块中的释放持续超过60小时。由纤维蛋白凝块形成的动脉内阻塞是暂时的，通过血管造影和病理检查在48小时内均观察到再通。
