Hassan Jacfar, Hyde Christian, Joiner Michael, Miller Steven Raymond
Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
SAGE Open Med Case Rep. 2024 Aug 22;12:2050313X241274218. doi: 10.1177/2050313X241274218. eCollection 2024.
High-grade gliomas (HGGs) are the most aggressive of brain tumors and are one of the most common primary intracranial malignancies. The poor prognosis after aggressive treatment of HGGs makes these gliomas a challenge to treat with curative intent. Proton radiation therapy is a recent radiation modality that is being explored for the treatment of HGGs. Proton radiation therapy provides improved sparing of critical normal structures while giving an ablative dose of radiation to the tumor, which can be performed more accurately than photon beam radiation therapy. We report a case of a diffuse HGG treated with proton radiotherapy and chemotherapy after previously being treated with photon irradiation. A complete radiographic response was seen on MRI imaging after proton irradiation.
高级别胶质瘤（HGGs）是最具侵袭性的脑肿瘤，也是最常见的原发性颅内恶性肿瘤之一。HGGs积极治疗后的预后较差，这使得这些胶质瘤难以实现治愈性治疗。质子放射治疗是一种最近正在探索用于治疗HGGs的放射治疗方式。质子放射治疗在向肿瘤给予消融剂量辐射的同时，能更好地保护关键正常结构，并且比光子束放射治疗执行得更精确。我们报告一例弥漫性HGG患者，该患者在先前接受光子照射后接受了质子放疗和化疗。质子照射后，MRI成像显示完全的影像学缓解。
