蛋白质病中用于正电子发射断层扫描成像的新兴靶点。
Emerging targets for positron emission tomography imaging in proteinopathies.
作者信息
Chassé Melissa, Vasdev Neil
机构信息
Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, ON Canada.
Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON Canada.
出版信息
Npj Imaging. 2024;2(1):30. doi: 10.1038/s44303-024-00032-4. Epub 2024 Aug 21.
Positron emission tomography (PET) imaging of neurodegenerative disease has historically focused on a small number of established targets. The development of selective PET radiotracers for novel biological targets enables new ways to interrogate the neuropathology of proteinopathies and will advance our understanding of neurodegeneration. This perspective aims to highlight recent PET radiotracers developed for five emerging targets in proteinopathies (i.e., mHTT, BACE1, TDP-43, OGA, and CH24H).
正电子发射断层扫描（PET）对神经退行性疾病的成像在历史上一直聚焦于少数已确定的靶点。针对新型生物学靶点开发选择性PET放射性示踪剂，为探究蛋白质病的神经病理学提供了新方法，并将推动我们对神经退行性变的理解。本观点旨在突出为蛋白质病的五个新兴靶点（即突变型亨廷顿蛋白、β-分泌酶1、TDP-43、O-连接N-乙酰葡糖胺酶和胆固醇24-羟化酶）开发的近期PET放射性示踪剂。
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