基于先进脑正电子发射断层扫描的分子成像在神经退行性蛋白质病生物学框架中的应用。
Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies.
作者信息
Perani Daniela, Iaccarino Leonardo, Jacobs Andreas H
机构信息
Vita-Salute San Raffaele University, Milan, Italy.
In Vivo Human Molecular and Structural Neuroimaging Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
出版信息
Alzheimers Dement (Amst). 2019 Apr 16;11:327-332. doi: 10.1016/j.dadm.2019.02.004. eCollection 2019 Dec.
INTRODUCTION
A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 "Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration," aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia.
METHODS
We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques.
RESULTS
This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias.
DISCUSSION
The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.
引言
在成像生物标志物可用性不断提高的推动下，神经退行性疾病正迅速从基于临床的分类向基于病理学的分类转变。由欧盟联合计划——2016年神经退行性疾病研究“神经退行性疾病脑成像方法协调与统一工作组”资助的创新多示踪剂分子脑成像框架，旨在为既定和新的分子成像技术在痴呆症中的应用提供路线图。
方法
我们考虑采用基于病理学的框架对正电子发射断层扫描技术的使用和开发的当前及未来影响。
结果
这种方法将加强对阿尔茨海默病和其他痴呆症多因素病因的理解。
讨论
病理学生物标志物的可用性将很快改变临床和研究实践。至关重要的是，对这些技术的优势和注意事项有全面的了解将促进明智地使用，以充分利用这些工具。
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