HIV 感染者中肛门 Merkel 细胞多瘤病毒和 HPV 共同感染的比率较高。

High rates of anal Merkel Cell Polyomavirus and HPV co-infection among people living with HIV.

机构信息

Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.

Department of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Rome, Italy.

出版信息

J Med Virol. 2024 Aug;96(8):e29883. doi: 10.1002/jmv.29883.

DOI:10.1002/jmv.29883

PMID:39185677

Abstract

Knowledge of Human Polyomavirus (HPyV) infection in the anal area and its association with sexually transmitted infections such as Human Papillomavirus (HPV) and Human Immunodeficiency Virus (HIV) remains limited. Therefore, anal specimens from 150 individuals of both sexes were analyzed for screening purposes. HPV DNA was found in 50.7% of cases, with a predominance of high-risk (HR) genotypes. HPyV DNA was found in 39.3% of samples, with Merkel Cell Polyomavirus (MCPyV) being the most common, with a higher viral load than JCPyV and BKPyV. In addition, MCPyV viral load increased in people living with HIV (PLWH) with HPV infection (p < 0.0001).

摘要

人多瘤病毒（HPyV）在肛门区域的感染知识及其与人类乳头瘤病毒（HPV）和人类免疫缺陷病毒（HIV）等性传播感染的关联仍然有限。因此，对 150 名男女的肛门标本进行了筛查分析。发现 HPV DNA 存在于 50.7%的病例中，主要为高危（HR）基因型。在 39.3%的样本中发现了 HPyV DNA，其中 Merkel 细胞多瘤病毒（MCPyV）最为常见，病毒载量高于 JCPyV 和 BKPyV。此外，MCPyV 病毒载量在 HPV 感染的 HIV 感染者（PLWH）中增加（p<0.0001）。