Department of Orthopaedic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, 315010, P. R. China.
Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, the First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, 315010, P. R. China.
Small. 2024 Nov;20(47):e2401886. doi: 10.1002/smll.202401886. Epub 2024 Aug 26.
Achilles tendinopathy (AT) is an injury caused by overuse of the Achilles tendon or sudden force on the Achilles tendon, with a considerable inflammatory infiltrate. As Achilles tendinopathy progresses, inflammation and inflammatory factors affect the remodeling of the extracellular matrix (ECM) of the tendon. Gastrodin(Gas), the main active ingredient of Astrodia has anti-inflammatory, antioxidant, and anti-apoptotic properties. The small intestinal submucosa (SIS) is a naturally decellularized extracellular matrix(dECM)material and has a high content of growth factors as well as good biocompatibility. However, the reparative effects of SIS and Gas on Achilles tendinopathy and their underlying mechanisms remain unknown. Here, it is found that SIS hydrogel loaded with gastrodin restored the mechanical strength of the Achilles tendon, facilitated ECM remodeling, and restored ordered collagen arrangement by promoting the translocation of protein synthesis. It also decreases the expression of inflammatory factors and reduces the infiltration of inflammatory cells by inhibiting the NF-κB signaling pathway. It is believed that through further research, Gas + SIS may be used in the future for the treatment of Achilles tendinopathy and other Achilles tendon injury disorders.
跟腱病（AT）是由于跟腱过度使用或突然受力引起的损伤，伴有相当大的炎症浸润。随着跟腱病的进展，炎症和炎症因子会影响跟腱细胞外基质（ECM）的重塑。天麻素（Gas）是天麻的主要活性成分，具有抗炎、抗氧化和抗细胞凋亡的特性。小肠黏膜下层（SIS）是一种天然去细胞化的细胞外基质（dECM）材料，具有较高含量的生长因子和良好的生物相容性。然而，SIS 和 Gas 对跟腱病的修复作用及其潜在机制尚不清楚。在这里，发现负载天麻素的 SIS 水凝胶通过促进蛋白质合成的易位恢复了跟腱的机械强度，促进 ECM 重塑，并恢复了有序的胶原排列。它还通过抑制 NF-κB 信号通路降低炎症因子的表达并减少炎症细胞的浸润。相信通过进一步研究，Gas+SIS 将来可能用于治疗跟腱病和其他跟腱损伤疾病。
