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多孔微球经皮内注射地塞米松治疗大鼠跟腱炎的疗效：改善炎症和腱组织退变。

Therapeutic Efficacy of Intratendinous Delivery of Dexamethasone Using Porous Microspheres for Amelioration of Inflammation and Tendon Degeneration on Achilles Tendinitis in Rats.

机构信息

Department of Biomedical Science, College of Medicine, Korea University, Anam-dong, Seongbuk-gu, Seoul 02841, Republic of Korea.

Department of Orthopedic Surgery and Rare Diseases Institute, Korea University Medical College, Guro Hospital, #148, Guro-dong, Guro-gu, Seoul 08308, Republic of Korea.

出版信息

Biomed Res Int. 2020 Jan 21;2020:5052028. doi: 10.1155/2020/5052028. eCollection 2020.

DOI:10.1155/2020/5052028
PMID:32090096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6996678/
Abstract

Achilles tendinitis caused by overuse, aging, or gradual wear induces pain, swelling, and stiffness of Achilles tendon and leads to tendon rupture. This study was performed to investigate the suppression of inflammation responses in interleukin-1 (IL-1) stimulated tenocytes and the suppression of the progression of Achilles tendinitis-induced rat models using dexamethasone-containing porous microspheres (DEX/PMSs) for a sustained intratendinous DEX delivery. DEX from DEX/PMSs showed the sustained release of DEX. Treatment of IL-1-stimulated tenocytes with DEX/PMSs suppressed the mRNA levels for COX-2, IL-1, IL-6, and TNF-. The intratendinous injection of DEX/PMSs into Achilles tendinitis rats both decreased the mRNA levels for these cytokines and increased mRNA levels for anti-inflammatory cytokines IL-4 and IL-10 in tendon tissues. Furthermore, DEX/PMSs effectively prevented tendon degeneration by enhancing the collagen content and biomechanical properties. Our findings suggest that DEX/PMSs show great potential as a sustained intratendinous delivery system for ameliorating inflammation responses as well as tendon degeneration in Achilles tendinitis.

摘要

过度使用、衰老或逐渐磨损引起的跟腱炎会导致跟腱疼痛、肿胀和僵硬，并导致跟腱断裂。本研究旨在探讨地塞米松载多孔微球（DEX/PMSs）持续腱内递送地塞米松，抑制白细胞介素-1（IL-1）刺激的腱细胞中的炎症反应，并抑制实验性大鼠跟腱炎模型的进展。DEX/PMSs 中的 DEX 表现出持续释放。DEX/PMSs 处理 IL-1 刺激的腱细胞可抑制 COX-2、IL-1、IL-6 和 TNF-α 的 mRNA 水平。DEX/PMSs 向跟腱炎大鼠的腱内注射可降低这些细胞因子的 mRNA 水平，并增加腱组织中抗炎细胞因子 IL-4 和 IL-10 的 mRNA 水平。此外，DEX/PMSs 通过增强胶原含量和生物力学特性，有效地防止了腱退化。我们的研究结果表明，DEX/PMSs 具有作为改善跟腱炎中炎症反应和腱退化的持续腱内递送系统的巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d18/6996678/f23ed530e64e/BMRI2020-5052028.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d18/6996678/03a5e5e55b83/BMRI2020-5052028.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d18/6996678/3769a7612462/BMRI2020-5052028.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d18/6996678/d6f87334b74b/BMRI2020-5052028.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d18/6996678/390871628ff1/BMRI2020-5052028.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d18/6996678/aa9b5f643314/BMRI2020-5052028.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d18/6996678/f23ed530e64e/BMRI2020-5052028.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d18/6996678/03a5e5e55b83/BMRI2020-5052028.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d18/6996678/3769a7612462/BMRI2020-5052028.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d18/6996678/d6f87334b74b/BMRI2020-5052028.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d18/6996678/390871628ff1/BMRI2020-5052028.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d18/6996678/aa9b5f643314/BMRI2020-5052028.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d18/6996678/f23ed530e64e/BMRI2020-5052028.006.jpg

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