Claus Mandy, Luppa Melanie, Zülke Andrea, Blotenberg Iris, Cardona Maria Isabel, Döhring Juliane, Escales Catharina, Kosilek Robert Philipp, Oey Anke, Zöllinger Isabel, Brettschneider Christian, Czock David, Frese Thomas, Gensichen Jochen, Hoffmann Wolfgang, Kaduszkiewicz Hanna, König Hans-Helmut, Wiese Birgitt, Thyrian Jochen René, Riedel-Heller Steffi G
Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany.
German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
Aging Ment Health. 2025 Mar;29(3):400-407. doi: 10.1080/13607863.2024.2394591. Epub 2024 Aug 26.
Various dementia risk scores exist that assess different factors. We investigated the association between the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) score and modifiable risk factors in the Lifestyle for Brain Health (LIBRA) score in a German population at high risk of Alzheimer's disease.
Baseline data of 807 participants of AgeWell.de (mean age: 68.8 years (SD = 4.9)) were analysed. Stepwise multivariable regression was used to examine the association between the CAIDE score and additional risk factors of the LIBRA score. Additionally, we examined the association between dementia risk models and cognitive performance, as measured by the Montreal Cognitive Assessment.
High cognitive activity (β = -0.016, < 0.001) and high fruit and vegetable intake (β = -0.032, < 0.001) correlated with lower CAIDE scores, while diabetes was associated with higher CAIDE scores (β = 0.191; = 0.032). Although all were classified as high risk on CAIDE, 31.5% scored ≤0 points on LIBRA, indicating a lower risk of dementia. Higher CAIDE and LIBRA scores were associated with lower cognitive performance.
Regular cognitive activities and increased fruit and vegetable intake were associated with lower CAIDE scores. Different participants are classified as being at-risk based on the dementia risk score used.
存在多种评估不同因素的痴呆风险评分。我们在患阿尔茨海默病风险较高的德国人群中，研究了心血管危险因素、衰老与痴呆发病率（CAIDE）评分与脑健康生活方式（LIBRA）评分中可改变危险因素之间的关联。
分析了AgeWell.de的807名参与者的基线数据（平均年龄：68.8岁（标准差 = 4.9））。采用逐步多变量回归来检验CAIDE评分与LIBRA评分的其他危险因素之间的关联。此外，我们还检验了痴呆风险模型与蒙特利尔认知评估所测量的认知表现之间的关联。
高认知活动（β = -0.016，< 0.001）和高果蔬摄入量（β = -0.032，< 0.001）与较低的CAIDE评分相关，而糖尿病与较高的CAIDE评分相关（β = 0.191；= 0.032）。尽管所有参与者在CAIDE评分中都被归类为高风险，但31.5%的参与者在LIBRA评分中得分为≤0分，表明痴呆风险较低。较高的CAIDE和LIBRA评分与较低的认知表现相关。
规律的认知活动和增加果蔬摄入量与较低的CAIDE评分相关。根据所使用的痴呆风险评分，不同参与者被归类为有风险。
