Zhang Fengjun, Zou Qiong, Liu Qiuping, You Zhipeng
The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Jiangxi Province Key Laboratory of Ophthalmology and Vision Sciences, Nanchang, China.
Retina. 2024 Dec 1;44(12):2168-2176. doi: 10.1097/IAE.0000000000004231. Epub 2024 Nov 12.
To explore the clinical features and significance of "notch" in reactivation of retinopathy of prematurity (ROP) post-intravitreal ranibizumab (IVR) monotherapy.
Ninety-six infants (173 eyes) with Type 1 or aggressive ROP (A-ROP) post-IVR monotherapy were retrospectively analyzed; 51 eyes were notch (+) and 122 eyes were notch (-). General demographics and clinical outcomes were compared by notch status for Type 1 and A-ROP.
The notch primarily appeared in Stage 2 ROP (84.4% and 78.9%) at the junction of Zones I and II (68.8% and 63.2%) on the temporal side in Type 1 ROP and A-ROP. Notch was present in the Type 1 ROP group before first IVR but posttreatment in the A-ROP group. A significantly higher reactivation rate, longer follow-up duration, and postmenstrual age at the last follow-up were seen in the notch (+) versus the notch (-) group. In the notch (+) ROP group, the mean gestational age (28.34 ± 0.93 vs. 29.94 ± 1.48 weeks) was significantly lower in reactivated versus regressed eyes.
Notches appeared at different times but similar locations in Type 1 ROP and A-ROP. The reactivation rate after IVR was increased in ROP with notches. Notch may be a useful biomarker for reactivation after IVR in ROP.
探讨玻璃体内注射雷珠单抗（IVR）单药治疗后早产儿视网膜病变（ROP）再激活中“切口”的临床特征及意义。
回顾性分析96例接受IVR单药治疗后患有1型或侵袭性ROP（A-ROP）的婴儿（173只眼）；51只眼为切口（+），122只眼为切口（-）。按切口状态比较1型和A-ROP的一般人口统计学特征及临床结局。
切口主要出现在1型ROP和A-ROP的2期ROP（分别为84.4%和78.9%），位于颞侧I区和II区交界处（分别为68.8%和63.2%）。切口在1型ROP组首次IVR前出现，而在A-ROP组为治疗后出现。与切口（-）组相比，切口（+）组的再激活率显著更高、随访时间更长且末次随访时的孕龄更大。在切口（+）的ROP组中，再激活眼的平均胎龄（28.34±0.93周 vs. 29.94±1.48周）显著低于消退眼。
切口在1型ROP和A-ROP中出现时间不同但位置相似。有切口的ROP在IVR后的再激活率增加。切口可能是ROP中IVR后再激活的有用生物标志物。
