Humphries Leigh A, Applebaum Jeremy, Mainigi Monica A, Martin Caitlin E, Shah Divya K
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Fertil Steril. 2025 Feb;123(2):333-341. doi: 10.1016/j.fertnstert.2024.08.337. Epub 2024 Aug 24.
To identify independent predictors of a successful match to reproductive endocrinology and infertility (REI) fellowships, and to develop and internally validate a prediction model for REI match results.
Retrospective cohort study.
Reproductive endocrinology and infertility fellowship applications sent to the University of Pennsylvania from 2019 to 2023 (excluding 2020), which represented nearly all REI applicants nationally according to National Resident Matching Program data.
Demographics, education, training, and academic achievements.
MAIN OUTCOME MEASURE(S): Match result, confirmed through online search and communication with program administrators. Univariate analyses identified variables associated with match, which were then included in multivariable models to identify independent predictors. Bootstrapping was used to assess model discrimination and calibration. The final model was integrated into a web-based tool.
RESULT(S): Of 286 applications (99.0% of REI applications to the National Resident Matching Program), 199 (69.6%) resulted in a successful match. In univariate analyses, variables associated with match were younger age, attendance at an allopathic US medical school, United States Medical Licensing Examination (USMLE) and Council on Resident Education in Obstetrics and Gynecology scores, residency rank, residency affiliation with a fellowship, research experiences, first-author publications, abstracts/articles in progress, and poster presentations. In the adjusted model, independent predictors of match included residency affiliation with an REI fellowship (adjusted odds ratio [aOR], 5.43; 2.02-14.64), residency rank (aOR, 1.77; 1.25-2.50), USMLE score (aOR, 1.05; 1.02-1.08), at least one first-author publication (aOR, 2.32; 1.08-4.96), projects in progress (aOR, 1.26; 1.02-1.55), and poster presentations (aOR, 1.07; 1.00-1.15). Attendance at an international medical school was a negative predictor (aOR, 0.32; 0.11-0.88). The model achieved an area under the curve of 0.883, with 88.5% sensitivity and 65.8% specificity. A refined model without USMLE scores maintained strong performance (C-statistic, 0.85; 0.81-0.91; calibration slope, 0.91; 0.72-1.24).
CONCLUSION(S): Affiliation with an REI fellowship, residency reputation, and research output strongly predicted match success. Gender, race, and ethnicity were not major predictors, yet underrepresentation of certain racial and ethnic groups limited the power to detect potential differences. Our prediction model correctly classified >75% of candidates' match results. These findings may help candidates optimize applications and estimate chances of a successful match into REI fellowship, as well as assist programs in critically reviewing their selection criteria for fellowship match.
确定生殖内分泌与不孕症(REI) fellowship 成功匹配的独立预测因素,并开发和内部验证 REI 匹配结果的预测模型。
回顾性队列研究。
2019 年至 2023 年(不包括 2020 年)发送至宾夕法尼亚大学的生殖内分泌与不孕症 fellowship 申请,根据国家住院医师匹配计划数据,这些申请几乎代表了全国所有 REI 申请者。
人口统计学、教育、培训和学术成就。
通过在线搜索和与项目管理人员沟通确认的匹配结果。单因素分析确定与匹配相关的变量,然后将其纳入多变量模型以确定独立预测因素。采用自助法评估模型的区分度和校准度。最终模型被整合到一个基于网络的工具中。
在 286 份申请中(占向国家住院医师匹配计划提交的 REI 申请的 99.0%),199 份(69.6%)成功匹配。在单因素分析中,与匹配相关的变量包括年龄较小、就读于美国全科医学医学院、美国医学执照考试(USMLE)和妇产科住院医师教育委员会的分数、住院医师排名(residency rank)、与 fellowship 相关的住院医师附属关系(residency affiliation with a fellowship)、研究经历、第一作者发表的论文、正在进行的摘要/文章以及海报展示。在调整后的模型中,匹配的独立预测因素包括与 REI fellowship 相关的住院医师附属关系(调整后的优势比[aOR],5.43;2.02 - 14.64)、住院医师排名(aOR,1.77;1.25 - 2.50)、USMLE 分数(aOR,1.05;1.02 - 1.08)、至少一篇第一作者发表的论文(aOR,2.32;1.08 - 4.96)、正在进行的项目(aOR,1.26;1.02 - 1.55)以及海报展示(aOR,1.07;1.00 - 1.15)。就读于国际医学院是一个负向预测因素(aOR,0.32;0.11 - 0.88)。该模型的曲线下面积为 0.883,灵敏度为 88.5%,特异度为 65.8%。一个没有 USMLE 分数的优化模型保持了较强的性能(C 统计量,0.85;0.81 - 0.91;校准斜率,0.91;0.72 - 1.24)。
与 REI fellowship 的附属关系、住院医师声誉和研究产出强烈预测匹配成功。性别、种族和民族不是主要预测因素,但某些种族和民族群体的代表性不足限制了检测潜在差异的能力。我们的预测模型正确分类了超过 75%的候选人的匹配结果。这些发现可能有助于候选人优化申请并估计成功匹配到 REI fellowship 的机会,也有助于项目严格审查其 fellowship 匹配的选拔标准。