Cancer Biology and Inflammatory Disorder Division, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology (CSIR-IICB), TRUE Campus, CN-6, Sector-V, Salt Lake, Kolkata-700091 & Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201 002, India.
Department of Microbiology, Dhruba Chand Halder College, Dakshin Barasat, South 24 Paraganas, PIN - 743372, India.
Biochim Biophys Acta Mol Cell Res. 2024 Dec;1871(8):119827. doi: 10.1016/j.bbamcr.2024.119827. Epub 2024 Aug 24.
Colorectal cancer (CRC) presents ongoing challenges due to limited treatment effectiveness and a discouraging prognosis, underscoring the need for ground-breaking therapeutic approaches. This review delves into the pivotal role of E3 ubiquitin ligases and deubiquitinases (DUBs), underscoring their role as crucial regulators for tumor suppression and oncogenesis in CRC. We spotlight the diverse impact of E3 ligases and DUBs on CRC's biological processes and their remarkable versatility. We closely examine their specific influence on vital signaling pathways, particularly Wnt/β-catenin and NF-κB. Understanding these regulatory mechanisms is crucial for unravelling the complexities of CRC progression. Importantly, we explore the untapped potential of E3 ligases and DUBs as novel CRC treatment targets, discussing aspects that may guide more effective therapeutic strategies. In conclusion, our concise review illuminates the E3 ubiquitin ligases and deubiquitinases pivotal role in CRC, offering insights to inspire innovative approaches for transforming the treatment landscape in CRC.
结直肠癌（CRC）由于治疗效果有限和预后不佳而持续面临挑战，这凸显了需要开创性的治疗方法。本综述深入探讨了 E3 泛素连接酶和去泛素化酶（DUBs）的关键作用，强调它们作为 CRC 中肿瘤抑制和致癌作用的关键调节剂的作用。我们重点介绍了 E3 连接酶和 DUBs 对 CRC 生物学过程的多样化影响及其显著的多功能性。我们仔细研究了它们对重要信号通路（特别是 Wnt/β-catenin 和 NF-κB）的具体影响。了解这些调节机制对于揭示 CRC 进展的复杂性至关重要。重要的是，我们探讨了 E3 连接酶和 DUBs 作为新型 CRC 治疗靶点的未开发潜力，讨论了可能指导更有效的治疗策略的方面。总之，我们的简明综述阐明了 E3 泛素连接酶和去泛素化酶在 CRC 中的关键作用，为激发创新方法以改变 CRC 的治疗格局提供了新的思路。
