Department of Internal Medicine, The Fifth People's Hospital of Longgang District, Shenzhen, Guangdong, China.
Department of Pathology, The Fifth People's Hospital of Longgang District, Shenzhen, Guangdong, China.
J Stroke Cerebrovasc Dis. 2024 Nov;33(11):107963. doi: 10.1016/j.jstrokecerebrovasdis.2024.107963. Epub 2024 Aug 24.
Magnesium ion metabolism disorder is pervasive in the chronic kidney disease population, which is affected by many factors. Magnesium ion plays an important role in maintaining vascular functional integrity.. The Magnesium Depletion Score (MDS), serving as a novel metric for the assessment of magnesium deficiency, has not been thoroughly investigated for its association with stroke in patients with chronic kidney disease (CKD). Therefore, this study aims to explore the relationship between the MDS index and stroke in CKD patients.
We conducted a cross-sectional population-based study using data from the National Health and Nutrition Examination Survey 2009-2016 to explore the impact of MDS on the stroke outcome of CKD patients. The primary outcome was the risk of stroke in CKD patients. Sample-weighted multivariate logistic regression was used in our analysis.
In this study of 3536 CKD patients from the database, we found an 8.6 % prevalence of stroke with higher stroke risk in older individuals and males. Lower dietary magnesium intake and higher MDS scores were significantly associated with stroke risk. Multivariate logistic regression analysis revealed a dose-dependent relationship between MDS scores and stroke likelihood, independent of demographic and clinical factors. Subgroup analysis confirmed these findings, particularly in those with hypertension, diabetes, and obesity, without significant interactions (all p > 0.05).
Magnesium depletion is independently associated with a heightened stroke risk in chronic kidney disease patients.
镁离子代谢紊乱在慢性肾脏病患者中普遍存在，受多种因素影响。镁离子在维持血管功能完整性方面起着重要作用。镁耗竭评分（MDS）作为一种评估镁缺乏的新指标，其与慢性肾脏病（CKD）患者中风的关系尚未得到充分研究。因此，本研究旨在探讨 MDS 指数与 CKD 患者中风之间的关系。
我们使用 2009-2016 年全国健康和营养调查的数据进行了一项横断面基于人群的研究，以探讨 MDS 对 CKD 患者中风结局的影响。主要结局是 CKD 患者中风的风险。我们的分析采用了样本加权多变量逻辑回归。
在这项来自数据库的 3536 例 CKD 患者的研究中，我们发现中风的患病率为 8.6%，且年龄较大和男性的中风风险更高。较低的饮食镁摄入量和较高的 MDS 评分与中风风险显著相关。多变量逻辑回归分析显示，MDS 评分与中风可能性之间存在剂量依赖性关系，独立于人口统计学和临床因素。亚组分析证实了这些发现，特别是在高血压、糖尿病和肥胖患者中，但无显著交互作用（均 p>0.05）。
镁耗竭与慢性肾脏病患者中风风险增加独立相关。
