Quadri Maheen, Ariza Adolfo J, Tucker Jared M, Bea Jennifer W, King Eileen C, Kirk Shelley, Sweeney Brooke R, Santos Melissa, Silver Lucie, Roberts Karyn J, Binns Helen J
Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Child Obes. 2025 Jan;21(1):50-64. doi: 10.1089/chi.2023.0201. Epub 2024 Aug 26.
Factors associated with change in percent body fat (%BF) of children in pediatric weight management (PWM) care may differ from those associated with change in weight status. To describe %BF and weight status at initial visits to 14 PWM sites, identify differences by sex, and evaluate factors associated with change over 6 months. Initial visits of 2496 males and 2821 females aged 5-18 years were evaluated. %BF was measured using bioelectrical impedance analysis. Sex-specific logistic regressions [806 males (32.3%), 837 females (29.7%)] identified associations with primary outcomes: lower %BF and metabolically impactful ≥5-point drop in percent of the 95th BMI percentile (%BMIp95) over 6 months. At the initial visit, males had lower %BF and higher %BMIp95 than females. Over 6 months, males had significantly ( < 0.001) greater median drop in %BF (-1.4% vs. -0.4%) and %BMIp95 (-3.0% vs. -1.9%) and a higher frequency of decreased %BF (68.9% vs. 57.8%), but similar percentage with ≥5-point %BMIp95 drop (36.5% vs. 32.4%; = 0.080). For males, factors significantly associated with decreased %BF (older age, ≥6 visits, lack of developmental or depression/anxiety concerns) were not related to having a ≥5-point %BMIp95 drop. For females, lack of depression/anxiety concern was significantly associated with decreased %BF but was not associated with ≥5-point %BMIp95 drop. There are differences by sex in initial visit %BF and %BMIp95 and in characteristics associated with changes in these measures. PWM interventions should consider evaluating body composition and sex-stratifying outcomes.
儿童体重管理(PWM)护理中与儿童体脂百分比(%BF)变化相关的因素可能与体重状况变化相关因素不同。为了描述14个PWM站点初次就诊时的%BF和体重状况,按性别识别差异,并评估6个月内变化的相关因素。对2496名5至18岁男性和2821名女性的初次就诊情况进行了评估。使用生物电阻抗分析测量%BF。特定性别的逻辑回归分析[806名男性(32.3%),837名女性(29.7%)]确定了与主要结局的关联:较低的%BF以及6个月内第95百分位BMI百分比(%BMIp95)代谢影响性下降≥5分。初次就诊时,男性的%BF低于女性,%BMIp95高于女性。在6个月内,男性的%BF中位数下降幅度显著更大(<0.001)(-1.4%对-0.4%),%BMIp95下降幅度也更大(-3.0%对-1.9%),且%BF下降频率更高(68.9%对57.8%),但%BMIp95下降≥5分的比例相似(36.5%对32.4%;P = 0.080)。对于男性,与%BF下降显著相关的因素(年龄较大、就诊≥6次、无发育或抑郁/焦虑问题)与%BMIp95下降≥5分无关。对于女性,无抑郁/焦虑问题与%BF下降显著相关,但与%BMIp95下降≥5分无关。初次就诊时的%BF和%BMIp95以及这些指标变化相关特征存在性别差异。PWM干预应考虑评估身体成分并按性别分层结果。