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肾移植受者,有 HIV、HBV 和既往 HCV 感染史。

Kidney transplant recipient with history of HIV, HBV, and past HCV infection.

机构信息

Nephrology and Transplantation Division, UMAE, National Medical Center of the West, Mexican Institute of Social Security, Guadalajara, Mexico.

University Center of Health Sciences, University of Guadalajara, Guadalajara, Mexico.

出版信息

AIDS Res Ther. 2024 Aug 26;21(1):57. doi: 10.1186/s12981-024-00647-y.

Abstract

Chronic viral infections caused by the human immunodeficiency virus (HIV), hepatitis C (HCV), and hepatitis B (HBV) are common among patients with end-stage renal disease (ESKD). These infections were once considered contraindications to kidney transplantation due to potential risks associated with long-term immunosuppression. Improved management and antiviral therapies have changed the prognosis and survival of this group of patients, along with an increased experience in transplanting people with these viral infections. We report the first successful kidney transplant in an ESKD patient on hemodialysis with a history of concomitant HIV, HCV and HBV infection in Mexico.

摘要

慢性病毒感染由人类免疫缺陷病毒(HIV)、丙型肝炎(HCV)和乙型肝炎(HBV)引起,在终末期肾病(ESKD)患者中很常见。由于长期免疫抑制相关的潜在风险,这些感染曾被认为是肾移植的禁忌症。随着在移植这些病毒感染者方面经验的增加,对这些患者的管理和抗病毒治疗的改善改变了其预后和生存。我们报告了首例在墨西哥成功进行的肾移植,受者为一名正在接受血液透析的同时合并 HIV、HCV 和 HBV 感染的 ESKD 患者。

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Effect of kidney transplantation on outcomes among patients with hepatitis C.肾移植对丙型肝炎患者结局的影响。
J Am Soc Nephrol. 2011 Jun;22(6):1152-60. doi: 10.1681/ASN.2010060668. Epub 2011 May 5.

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