Williams P T, Haskell W L, Vranizan K M, Blair S N, Krauss R M, Superko H R, Albers J J, Frey-Hewitt B, Wood P D
Circulation. 1985 Mar;71(3):441-9. doi: 10.1161/01.cir.71.3.441.
In major prospective studies it has been reported that high heart rate at rest predicts the development of coronary heart disease (CHD) or cardiovascular disease (CVD) in men, but the mechanisms producing these relationships are unknown. Since lipoprotein levels contribute strongly to the risk of CHD and CVD, we examined the relationship of resting heart rate to plasma concentrations of high-density (HDL), low-density (LDL), and very low-density (VLDL) lipoproteins, apolipoprotein (apo) A-I and A-II, and serum concentrations of lipoprotein subfractions in 81 men to determine if atherogenic lipoproteins could potentially induce the reported association of heart rate with development of CHD or CVD. The significant (p less than or equal to .05) Spearman's correlations for resting heart rate vs HDL2 mass (rs = -.24), HDL3 mass (rs = -.40), HDL cholesterol (rs = -.36), apo A-I (rs = -.29), triglycerides (rs = .31), VLDL cholesterol (rs = .24), VLDL mass (rs = .27), and LDL mass of Sof 0-7 subfraction (rs = .30) lend support to our hypothesis of lipoprotein-induced relationships of CHD with heart rate. The correlations for resting heart rate vs triglycerides, HDL cholesterol, HDL3 mass, VLDL mass, and LDL mass of Sof 0-7 subfraction remain significant when adjusted for adiposity, age, smoking habits, diet, and physical fitness as measured by maximum aerobic power (VO2 max) or submaximal heart rate during a graded exercise test.
在一些大型前瞻性研究中，有报告称静息心率较高可预测男性冠心病（CHD）或心血管疾病（CVD）的发生，但产生这些关联的机制尚不清楚。由于脂蛋白水平对冠心病和心血管疾病的风险有很大影响，我们研究了81名男性静息心率与高密度（HDL）、低密度（LDL）和极低密度（VLDL）脂蛋白、载脂蛋白（apo）A-I和A-II的血浆浓度以及脂蛋白亚组分的血清浓度之间的关系，以确定致动脉粥样硬化脂蛋白是否可能导致所报告的心率与冠心病或心血管疾病发生之间的关联。静息心率与HDL2质量（rs = -0.24）、HDL3质量（rs = -0.40）、HDL胆固醇（rs = -0.36）、apo A-I（rs = -0.29）、甘油三酯（rs = 0.31）、VLDL胆固醇（rs = 0.24）、VLDL质量（rs = 0.27）以及Sof 0 - 7亚组分的LDL质量（rs = 0.30）之间的显著（p≤0.05）斯皮尔曼相关性支持了我们关于脂蛋白诱导冠心病与心率之间关系的假设。当根据肥胖、年龄、吸烟习惯、饮食以及通过最大有氧功率（VO2 max）或分级运动试验中的次最大心率测量的身体素质进行调整后，静息心率与甘油三酯、HDL胆固醇、HDL3质量、VLDL质量以及Sof 0 - 7亚组分的LDL质量之间的相关性仍然显著。
