Mercadante Sebastiano, Bellavia Giuseppe Massimo, Fusco Flavio, Adamoli Lucia, Scibilia Carla, Lo Cascio Alessio, Casuccio Alessandra
Regional Home Palliative Care Program, SAMOT, Palermo, Italy.
Main Regional Center for Supportive and Palliative Care, La Maddalena Cancer Center, Palermo, Italy.
Am J Hosp Palliat Care. 2024 Aug 27:10499091241278924. doi: 10.1177/10499091241278924.
Information regarding the nutrition profile of advanced cancer patients followed at home is lacking. The aim of this study was to assess the nutritional status of patients who were admitted to specialized home palliative care, and examine eventual factors associated with malnutrition.
Cross-sectional. Setting/subject: patients who were admitted to 2 specialized home palliative care programs.
A consecutive sample of patients admitted to home care was selected. Depression, anxiety, nausea, poor appetite, and poor well-being were measured by numerical scale 0-10. Mini nutritional assessment form (MNA-SF), fatigue assessment scale (FAS), and sarcopenia by SARC-F. were performed. The use of drugs used for anorexia, including corticosteroids, progestins, or others, was recorded.
Data of 135 patients were analyzed. Sixty-eight per cent and 77% of patients resulted to be malnourished and sarcopenic. In the multivariate regression analysis, anxiety ( = 0.036) and total FAS ( = 0.013) were independently associated with malnutrition. Fifty-five per cent of patients were receiving corticosteroids or megestol acetate. No significant associations with parameters examined were found.
The majority of advanced cancer patients admitted to home palliative care were malnourished independently of the primary tumor diagnosis. Indeed, fatigue and anxiety were independently associated with malnutrition.
缺乏关于在家接受随访的晚期癌症患者营养状况的信息。本研究的目的是评估接受专门的家庭姑息治疗的患者的营养状况，并检查与营养不良相关的潜在因素。
横断面研究。地点/对象：纳入两个专门的家庭姑息治疗项目的患者。
选取连续入住家庭护理的患者样本。通过0-10数字量表测量抑郁、焦虑、恶心、食欲不佳和幸福感。采用微型营养评定量表（MNA-SF）、疲劳评定量表（FAS）以及通过SARC-F评估肌肉减少症。记录使用的用于治疗厌食的药物，包括皮质类固醇、孕激素或其他药物。
分析了135例患者的数据。68%和77%的患者存在营养不良和肌肉减少症。在多变量回归分析中，焦虑（P = 0.036）和FAS总分（P = 0.013）与营养不良独立相关。55%的患者正在接受皮质类固醇或醋酸甲地孕酮治疗。未发现与所检查参数有显著关联。
入住家庭姑息治疗的大多数晚期癌症患者存在营养不良，与原发性肿瘤诊断无关。事实上，疲劳和焦虑与营养不良独立相关。
