Bukenya George, Sloan Anthony R, Lathia Justin D
Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Case Comprehensive Cancer Center, Cleveland, OH, USA.
Mol Ther Oncol. 2024 Aug 6;32(3):200853. doi: 10.1016/j.omton.2024.200853. eCollection 2024 Sep 19.
Pleomorphic xanthoastrocytoma (PXA) is a rare pediatric low-grade glioma (pLGG), of which 60%-80% exhibit the BRAF V600E mutation, that enhances the aggressiveness and progression to an eventual pediatric high-grade glioma (pHGG). Despite the aggressiveness of this mutational status, the mechanisms underlying the progression of BRAF V600E tumors remain poorly understood, primarily due to limited insights into their growth dynamics. In this issue, Rajappa and colleagues leverage a novel immunocompetent RCAS-BRAF V600E murine glioma model to profile the immunological dynamics taking place in BRAF V600E pLGG.
多形性黄色星形细胞瘤（PXA）是一种罕见的儿童低级别胶质瘤（pLGG），其中60%-80%表现出BRAF V600E突变，该突变会增强肿瘤的侵袭性，并进展为最终的儿童高级别胶质瘤（pHGG）。尽管这种突变状态具有侵袭性，但BRAF V600E肿瘤进展的潜在机制仍知之甚少，主要是因为对其生长动力学的了解有限。在本期杂志中，拉贾帕及其同事利用一种新型的具有免疫活性的RCAS-BRAF V600E小鼠胶质瘤模型，来描绘BRAF V600E pLGG中发生的免疫动力学。
