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脑肿瘤的体内模型：基因工程小鼠模型在理解肿瘤生物学及临床前研究中的作用。

In vivo models of brain tumors: roles of genetically engineered mouse models in understanding tumor biology and use in preclinical studies.

作者信息

Simeonova Iva, Huillard Emmanuelle

机构信息

Université Pierre et Marie Curie (UPMC) UMR-S975, Inserm U1127, CNRS UMR7225, Institut du Cerveau et de la Moelle Epiniere, 47 boulevard de l'Hôpital, 75013, Paris, France.

出版信息

Cell Mol Life Sci. 2014 Oct;71(20):4007-26. doi: 10.1007/s00018-014-1675-3. Epub 2014 Jul 10.

DOI:10.1007/s00018-014-1675-3
PMID:25008045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4175043/
Abstract

Although our knowledge of the biology of brain tumors has increased tremendously over the past decade, progress in treatment of these deadly diseases remains modest. Developing in vivo models that faithfully mirror human diseases is essential for the validation of new therapeutic approaches. Genetically engineered mouse models (GEMMs) provide elaborate temporally and genetically controlled systems to investigate the cellular origins of brain tumors and gene function in tumorigenesis. Furthermore, they can prove to be valuable tools for testing targeted therapies. In this review, we discuss GEMMs of brain tumors, focusing on gliomas and medulloblastomas. We describe how they provide critical insights into the molecular and cellular events involved in the initiation and maintenance of brain tumors, and illustrate their use in preclinical drug testing.

摘要

尽管在过去十年里，我们对脑肿瘤生物学的认识有了极大的提高，但这些致命疾病的治疗进展仍然有限。开发能够忠实地反映人类疾病的体内模型对于验证新的治疗方法至关重要。基因工程小鼠模型（GEMMs）提供了精心设计的、在时间和基因上可控的系统，用于研究脑肿瘤的细胞起源以及肿瘤发生过程中的基因功能。此外，它们可被证明是测试靶向治疗的有价值工具。在这篇综述中，我们讨论脑肿瘤的基因工程小鼠模型，重点是胶质瘤和髓母细胞瘤。我们描述了它们如何为脑肿瘤的起始和维持所涉及的分子和细胞事件提供关键见解，并阐述了它们在临床前药物测试中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28a/11113381/fb24fcd8649d/18_2014_1675_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28a/11113381/fb24fcd8649d/18_2014_1675_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28a/11113381/fb24fcd8649d/18_2014_1675_Fig1_HTML.jpg

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