Petruzzi Massimo
Interdisciplinary Department of Medicine, School of Dentistry, University of Bari Aldo Moro, Bari, Italy.
Department of Restorative, Preventive and Pediatric Dentistry, University of Bern, Bern, Switzerland.
Front Oral Health. 2024 Aug 12;5:1456385. doi: 10.3389/froh.2024.1456385. eCollection 2024.
Nikolsky's sign, originally described for skin lesions, presents challenges when applied to the oral mucosa. To address this, a modified Nikolsky's sign has been proposed specifically for the oral mucosa. In this variant, a gentle breath of air from the air syringe embedded in the dental unit is used to inflate a pre-existing collapsed blister (non-induced technique). Alternatively, in the induced technique, a healthy peri-lesion mucosal site is gently scratched with a blunt dental tool, and after a few minutes, air is blown on the same area to inflate any newly formed blister. The sign is considered positive if a blister is raised from the blown surface. The described modified Nikolsky's sign improves the visualization of oral vesicles and blisters in a cost-effective, easy, and minimally invasive manner. Its elicitation can aid in referring patients to specialized tertiary care units.
尼氏征最初用于描述皮肤病变，应用于口腔黏膜时存在挑战。为解决这一问题，专门针对口腔黏膜提出了改良尼氏征。在这种变体中，使用牙科设备中嵌入的空气注射器轻轻吹气，使预先存在的塌陷水疱膨胀（非诱发技术）。或者，在诱发技术中，用钝的牙科工具轻轻刮擦病变周围健康的黏膜部位，几分钟后，在同一区域吹气，使任何新形成的水疱膨胀。如果吹气表面出现水疱，则该体征被认为是阳性。所描述的改良尼氏征以经济有效、简便且微创的方式改善了口腔水疱的可视化。其引出有助于将患者转诊至专业的三级护理单位。
