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尼氏征：一种具有诊断价值的体征。

Nikolsky's sign: A pathognomic boon.

作者信息

Maity Subhadeep, Banerjee Ishita, Sinha Rupam, Jha Harshvardhan, Ghosh Pritha, Mustafi Subhasish

机构信息

Department of Oral Medicine and Radiology, Haldia Institute of Dental Sciences and Research, Haldia, West Bengal, India.

Department of Dental Surgery, Haldia Institute of Dental Sciences and Research, Haldia, West Bengal, India.

出版信息

J Family Med Prim Care. 2020 Feb 28;9(2):526-530. doi: 10.4103/jfmpc.jfmpc_889_19. eCollection 2020 Feb.

DOI:10.4103/jfmpc.jfmpc_889_19
PMID:32318376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7114071/
Abstract

Nikolsky's sign has been a very useful diagnostic tool in cases of skin disorders like pemphigus, toxic epidermal necrolysis, etc., The sign is demonstrated when lateral pressure is applied on the border of an intact blister, which results in the dislodgment of the normal epidermis and extension of the blister.

摘要

尼氏征在天疱疮、中毒性表皮坏死松解症等皮肤疾病的诊断中一直是非常有用的工具。当在完整水疱边缘施加侧向压力时，会出现该体征，这会导致正常表皮脱落，水疱扩大。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb5/7114071/f31c1c947d15/JFMPC-9-526-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb5/7114071/d69ebfff2130/JFMPC-9-526-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb5/7114071/9c5379d042d6/JFMPC-9-526-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb5/7114071/16b0404ff54f/JFMPC-9-526-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb5/7114071/e7c1352b10ef/JFMPC-9-526-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb5/7114071/f31c1c947d15/JFMPC-9-526-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb5/7114071/d69ebfff2130/JFMPC-9-526-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb5/7114071/9c5379d042d6/JFMPC-9-526-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb5/7114071/16b0404ff54f/JFMPC-9-526-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb5/7114071/e7c1352b10ef/JFMPC-9-526-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb5/7114071/f31c1c947d15/JFMPC-9-526-g005.jpg

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本文引用的文献

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Pemphigus: Current and Future Therapeutic Strategies.天疱疮：当前和未来的治疗策略。
Front Immunol. 2019 Jun 25;10:1418. doi: 10.3389/fimmu.2019.01418. eCollection 2019.
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Pemphigus vulgaris - A report of three cases and review of literature.寻常型天疱疮——三例报告及文献综述
J Family Med Prim Care. 2018 Sep-Oct;7(5):1109-1112. doi: 10.4103/jfmpc.jfmpc_133_18.
3
Stevens-Johnson syndrome and toxic epidermal necrolysis.史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症。
青少年寻常型天疱疮：一篇综述
Medicine (Baltimore). 2025 May 23;104(21):e42611. doi: 10.1097/MD.0000000000042611.
4
Case report: Toxic epidermal necrolysis as a unique presentation of acute graft versus host disease in a pediatric patient.病例报告：中毒性表皮坏死松解症作为一名儿科患者急性移植物抗宿主病的独特表现。
Front Immunol. 2025 Jan 23;15:1452245. doi: 10.3389/fimmu.2024.1452245. eCollection 2024.
5
Update on Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Diagnosis and Management.史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症的最新进展：诊断与治疗。
Am J Clin Dermatol. 2024 Nov;25(6):891-908. doi: 10.1007/s40257-024-00889-6. Epub 2024 Sep 15.
6
Proposal of a modified technique of Nikolsky's sign in oral autoimmune vesiculobullous diseases.口腔自身免疫性水疱性疾病中Nikolsky征改良技术的提议。
Front Oral Health. 2024 Aug 12;5:1456385. doi: 10.3389/froh.2024.1456385. eCollection 2024.
7
Delayed diagnosis of pemphigus vulgaris in rural Nepal due to healthcare inaccessibility and harmful traditional practices: A case report.尼泊尔农村地区因医疗服务不可及和有害传统习俗导致寻常型天疱疮延迟诊断：一例报告
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Allopurinol-Induced Toxic Epidermal Necrolysis.别嘌醇诱发的中毒性表皮坏死松解症。
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8
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Arch Dermatol. 1987 Sep;123(9):1122-3.