Alzahrani Mazen, Alammari Omer, Binyamin Abdulelah, Alsulami Raed, Hawsawi Rawan
Department of Anterior Segment, Jeddah Eye Hospital, Jeddah, Saudi Arabia.
Department of Anterior Segment, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
Clin Ophthalmol. 2024 Aug 22;18:2349-2355. doi: 10.2147/OPTH.S460464. eCollection 2024.
The aim of this study was to assess changes in corneal parameters 6 months after corneal cross-linking for progressive keratoconus, using the ABCD system.
This retrospective study was conducted at the King Khaled Eye Specialist Hospital (Riyadh, Saudi Arabia) between January 1 and July 30, 2022. This study included 16 eyes of 16 patients with keratoconus who underwent corneal cross-linking at the same hospital and were at least 18 years old. At least one preoperative (T0) and one postoperative examination was performed for each patient. Six months after the procedure (T1), patients underwent corneal tomography. The parameters A, B, C, and D were also evaluated. Other parameters monitored included maximal keratometry (Kmax) (K1 and K2), Belin/Ambrósio Enhanced Ectasia Display, and index vertical asymmetry. The progression of ectasia was identified by a consistent change in at least two parameters: steepening of the anterior corneal surface or the posterior corneal surface, thinning or an increase in the rate at which the corneal thickness changed from the periphery to the thinnest point, where the magnitude of the change was greater than the normal noise of the testing system.
Among the patients, 68.8% were men. The patients' average age was 25.8±5 years. Throughout the 6-month postoperative follow-up, parameters A, B, and C exhibited substantial changes (P = 0.000 for parameters A, B, and C). Parameter A increased 6 months after surgery, whereas parameters B and C decreased. Preoperatively and 6 months after surgery, Kmax, K1, and Belin/Ambrosio-enhanced ectasia demonstrated substantial differences. However, parameter D, K2, and the average pachymetric progression index did not change significantly.
Anterior and posterior corneal curvatures and corneal thickness profiles can be useful for monitoring the progression of keratoconus and the success of the corneal cross-linking operation.
本研究旨在使用ABCD系统评估圆锥角膜交联术后6个月角膜参数的变化。
本回顾性研究于2022年1月1日至7月30日在沙特阿拉伯利雅得的哈立德国王眼科专科医院进行。本研究纳入了16例在同一家医院接受角膜交联且年龄至少为18岁的圆锥角膜患者的16只眼。每位患者至少进行了一次术前（T0）和一次术后检查。术后6个月（T1），患者接受角膜断层扫描。还评估了参数A、B、C和D。监测的其他参数包括最大角膜曲率（Kmax）（K1和K2）、贝林/安布罗西奥增强型扩张显示以及指数垂直不对称性。通过至少两个参数的一致变化来确定扩张的进展：角膜前表面或后表面变陡、角膜厚度从周边到最薄点的变化率变薄或增加，其中变化幅度大于测试系统的正常噪声。
患者中68.8%为男性。患者的平均年龄为25.8±5岁。在术后6个月的随访中，参数A、B和C出现了显著变化（参数A、B和C的P值均为0.000）。术后6个月参数A增加，而参数B和C降低。术前和术后6个月，Kmax、K1和贝林/安布罗西奥增强型扩张显示出显著差异。然而，参数D、K2和平均角膜厚度进展指数没有显著变化。
角膜前后曲率和角膜厚度剖面图可用于监测圆锥角膜的进展以及角膜交联手术的成功与否。
