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环四肽衣原体毒素和HC毒素的相互生物学活性。

Reciprocal biological activities of the cyclic tetrapeptides chlamydocin and HC-toxin.

作者信息

Walton J D, Earle E D, Stähelin H, Grieder A, Hirota A, Suzuki A

出版信息

Experientia. 1985 Mar 15;41(3):348-50. doi: 10.1007/BF02004498.

DOI:10.1007/BF02004498
PMID:3918884
Abstract

Chlamydocin, a potent cytostatic agent against cultured mammalian cells, and HC-toxin, a host-specific phytotoxin, are cyclic tetrapeptides containing the same epoxide alpha-amino acid. We show here that these compounds have reciprocal biological activity; HC-toxin is cytostatic against cultured mastocytoma cells, and chlamydocin has host-specific toxin activity against maize. Chlamydocin and another related cyclic peptide, Cyl-2, are less host-specific than HC-toxin because maize tolerant to HC-toxin is more sensitive to chlamydocin and Cyl-2.

摘要

衣原体霉素是一种对培养的哺乳动物细胞有强效抑制细胞生长作用的药物，而HC毒素是一种宿主特异性植物毒素，它们都是含有相同环氧化α-氨基酸的环四肽。我们在此表明，这些化合物具有相互的生物活性；HC毒素对培养的肥大细胞瘤细胞有抑制细胞生长的作用，而衣原体霉素对玉米具有宿主特异性毒素活性。与HC毒素相比，衣原体霉素和另一种相关的环肽Cyl-2的宿主特异性较低，因为对HC毒素耐受的玉米对衣原体霉素和Cyl-2更敏感。

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Experientia. 1985 Mar 15;41(3):348-50. doi: 10.1007/BF02004498.
2
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本文引用的文献

1
Purification and structure of the host-specific toxin from Helminthosporium carbonum race 1.来自玉米小斑病菌1号小种的寄主专化性毒素的纯化与结构
Biochem Biophys Res Commun. 1982 Aug;107(3):785-94. doi: 10.1016/0006-291x(82)90592-7.
2
Conformational studies of cyclic tetrapeptides. Evidence for a bis gamma-turn conformation for chlamydocin and Ala4-chlamydocin in nonpolar solvents.环四肽的构象研究。在非极性溶剂中衣原体毒素和丙氨酸4-衣原体毒素呈双γ-转角构象的证据。
Int J Pept Protein Res. 1983 Jan;21(1):35-42.
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Histone Hyperacetylation in Maize in Response to Treatment with HC-Toxin or Infection by the Filamentous Fungus Cochliobolus carbonum.玉米中组蛋白的高度乙酰化对HC毒素处理或丝状真菌玉米炭疽菌感染的响应
Plant Physiol. 1997 Nov;115(3):1021-1027. doi: 10.1104/pp.115.3.1021.
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Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum.HC毒素（玉米小斑病菌的寄主选择性毒素）对玉米组蛋白脱乙酰酶的抑制作用。
Plant Cell. 1995 Nov;7(11):1941-50. doi: 10.1105/tpc.7.11.1941.
HC毒素的结构与构象。
Biochem Biophys Res Commun. 1983 Mar 16;111(2):398-403. doi: 10.1016/0006-291x(83)90319-4.
4
[Isolation and structural clarification of chlamydocin].[衣原体霉素的分离与结构解析]
Helv Chim Acta. 1974 Apr 27;57(3):533-45. doi: 10.1002/hlca.19740570306.
5
Mass spectrometric determination of amino acid sequence in Cyl-2, a novel cyclotetrapeptide from Cylindrocladium scoparium.柱孢圆柱孢菌中新型环四肽Cyl-2氨基酸序列的质谱测定
Biomed Mass Spectrom. 1974 Feb;1(1):15-9. doi: 10.1002/bms.1200010106.
6
Cytostatic activity of chlamydocin, a rapidly inactivated cyclic tetrapeptide.短杆菌肽，一种快速失活的环四肽的细胞生长抑制活性。
Eur J Cancer (1965). 1974 Dec;10(12):801-8. doi: 10.1016/0014-2964(74)90137-6.
7
Comparative study of early effects of epipodophyllotoxin derivatives and other cytostatic agents on mastocytoma cultures.鬼臼毒素衍生物与其他细胞抑制剂对肥大细胞瘤培养物早期作用的比较研究。
Cancer Res. 1977 Sep;37(9):2998-3005.