Reactions of the semiquinone free radicals of anti-tumour agents with oxygen and iron complexes.
作者信息
Butler J, Hoey B M, Swallow A J
出版信息
FEBS Lett. 1985 Mar 11;182(1):95-8. doi: 10.1016/0014-5793(85)81161-3.
PMID:3918891
Abstract
The rates of reaction of the semiquinone radicals of adriamycin and mitomycin C with oxygen and several iron (III) complexes have been determined. These rates have been used to explain enhanced free radical damage produced by semiquinone radicals in a model system and to assess the feasibility of these types of reactions occurring in hypoxic cells.
摘要
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