Dai Rui, Niu Ziran, Yang Yang, Liu Xin, Zhang Bo
Department of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Clinical Pharmacology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Front Pharmacol. 2024 Aug 12;15:1403390. doi: 10.3389/fphar.2024.1403390. eCollection 2024.
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare and severe cutaneous adverse drug reactions (SCARs) with high mortality. Antibiotics are the most frequent causative agents related to DRESS. However, it is rarely reported in cephalosporins, especially for ceftazidime. Here, we reported a case of ceftazidime-induced DRESS with HLA genotypic polymorphism as a risk factor. A 58-year-old woman with connective tissue disease was intravenously infused with ceftazidime for the treatment of pneumonia and intestinal infection, followed by the presence of fever, rash, and hematologic and hepatic laboratory abnormalities. DRESS was diagnosed and the positive polymorphism in HLA-B*15:02 was found. Our case illustrated the necessity to clarify the patho-mechanism and the use of pretreatment HLA analysis to prevent ceftazidime-related DRESS may be a valuable option soon.
药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）是一种罕见且严重的皮肤不良反应（SCARs），死亡率很高。抗生素是与DRESS相关最常见的致病因素。然而，头孢菌素类药物引起的DRESS很少见，尤其是头孢他啶。在此，我们报告一例以HLA基因多态性为危险因素的头孢他啶诱发的DRESS病例。一名患有结缔组织病的58岁女性因肺炎和肠道感染静脉输注头孢他啶治疗，随后出现发热、皮疹以及血液学和肝脏实验室检查异常。诊断为DRESS，并发现HLA - B*15:02呈阳性多态性。我们的病例表明，阐明发病机制以及使用预处理HLA分析来预防头孢他啶相关的DRESS可能很快会成为一种有价值的选择。
