Zhao Zhe, Lu Ming, Ying Yingqiu
Department of Pharmacy, Peking University Third Hospital, Beijing, China.
Institute for Drug Evaluation, Peking University Health Science Center, Beijing, China.
Front Pharmacol. 2024 Mar 7;15:1355774. doi: 10.3389/fphar.2024.1355774. eCollection 2024.
Minocycline is a tetracycline commonly used for several dermatological diseases. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but severe adverse event which can be caused by minocycline. An 18-year-old male patient developed fever, acute rash, pharyngeal pain, lymphadenopathy, hematologic abnormalities, increased creatinine level, elevated liver enzyme levels, and splenomegaly 4 weeks after the oral treatment of minocycline, 100 mg daily, for acne. Once diagnosed with DRESS syndrome, intravenous methylprednisolone was applied and his clinical manifestations and laboratory results remarkably improved. Then, a total of 13 DRESS syndrome cases induced by minocycline were reviewed and their clinical characteristics were summarized. In these cases, only two patient (15.4%) was present with pharynx involved. In conclusion, we reported a rare minocycline-induced DRESS syndrome who developed fever, eosinophilia, acute rash, pharyngitis, lymphadenopathy, acute kidney injury, hepatitis, and splenomegaly. Our report provides detailed clinical features of minocycline-induced DRESS syndrome, which helps us further understand this severe adverse event.
米诺环素是一种常用于多种皮肤病的四环素类药物。药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征是一种罕见但严重的不良事件，可由米诺环素引起。一名18岁男性患者在口服米诺环素（每日100毫克）治疗痤疮4周后，出现发热、急性皮疹、咽痛、淋巴结病、血液学异常、肌酐水平升高、肝酶水平升高和脾肿大。一旦诊断为DRESS综合征，即应用静脉注射甲泼尼龙，其临床表现和实验室检查结果显著改善。然后，回顾了总共13例由米诺环素引起的DRESS综合征病例，并总结了其临床特征。在这些病例中，只有两名患者（15.4%）累及咽部。总之，我们报告了一例罕见的由米诺环素引起的DRESS综合征，患者出现发热、嗜酸性粒细胞增多、急性皮疹、咽炎、淋巴结病、急性肾损伤、肝炎和脾肿大。我们的报告提供了米诺环素引起的DRESS综合征的详细临床特征，有助于我们进一步了解这一严重不良事件。
