Zhu Yuan, Su Sheng-An, Shen Jian, Ma Hong, Le Jixie, Xie Yao, Xiang Meixiang
Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
State Key Laboratory of Transvascular Implantation Devices, Hangzhou 310009, China.
iScience. 2024 Jul 19;27(8):110556. doi: 10.1016/j.isci.2024.110556. eCollection 2024 Aug 16.
Erythropoietin-producing hepatoma (Eph) receptors, comprising the largest family of receptor tyrosine kinases (RTKs), exert profound influence on diverse biological processes and pathological conditions such as cancer. Interacting with their corresponding ligands, erythropoietin-producing hepatoma receptor interacting proteins (Ephrins), Eph receptors regulate crucial events like embryonic development, tissue boundary formation, and tumor cell survival. In addition to their well-established roles in embryonic development and cancers, emerging evidence highlights the pivotal contribution of the Ephrin/Eph family to cardiovascular physiology and pathology. Studies have elucidated their involvement in cardiovascular development, atherosclerosis, postnatal angiogenesis, and, more recently, cardiac fibrosis and calcification, suggesting a promising avenue for therapeutic interventions in cardiovascular diseases. There remains a need for a comprehensive synthesis of their collective impact in the cardiovascular context. By exploring the intricate interactions between Eph receptors, ephrins, and cardiovascular system, this review aims to provide a holistic understanding of their roles and therapeutic potential in cardiovascular health and diseases.
促红细胞生成素产生性肝癌（Eph）受体是受体酪氨酸激酶（RTK）中最大的家族，对多种生物过程和病理状况（如癌症）产生深远影响。通过与相应配体——促红细胞生成素产生性肝癌受体相互作用蛋白（Ephrins）相互作用，Eph受体调节诸如胚胎发育、组织边界形成和肿瘤细胞存活等关键事件。除了在胚胎发育和癌症中已确立的作用外，新出现的证据凸显了Ephrin/Eph家族对心血管生理和病理的关键贡献。研究已阐明它们参与心血管发育、动脉粥样硬化、出生后血管生成，以及最近发现的心脏纤维化和钙化，这表明在心血管疾病的治疗干预方面有一条很有前景的途径。仍然需要全面综合它们在心血管背景下的总体影响。通过探索Eph受体、Ephrins与心血管系统之间的复杂相互作用，本综述旨在全面了解它们在心血管健康和疾病中的作用及治疗潜力。
