Rudno-Rudzińska Julia, Kielan Wojciech, Frejlich Ewelina, Kotulski Krzysztof, Hap Wojciech, Kurnol Krzysztof, Dzierżek Przemysław, Zawadzki Marcin, Hałoń Agnieszka
2-nd Department of General and Oncological Surgery.
Pathology Department, Wrocław Medical University, Borowska 213, 50-556 Wrocław, Poland.
Chin J Cancer Res. 2017 Aug;29(4):303-312. doi: 10.21147/j.issn.1000-9604.2017.04.03.
Erythroprotein-producing human hepatocellular carcinoma receptors (Eph receptors) compose a subfamily of transmembrane protein-tyrosine kinases receptors that takes part in numerous physiological and pathological processes. Eph family receptor-interacting proteins (Ephrins) are ligands for those receptors. Eph/ephrin system is responsible for the cytoskeleton activity, cell adhesion, intercellular connection, cellular shape as well as cell motility. It affects neuron development and functioning, bone and glucose homeostasis, immune system and correct function of enterocytes. Moreover Eph/ephrin system is one of the crucial ones in angiogenesis and lymphangiogenesis. With such a wide range of impact it is clear that disturbed function of this system leads to pathology. Eph/ephrin system is involved in carcinogenesis and cancer progression. Although the idea of participation of ephrin in carcinogenesis is obvious, the exact way remains unclear because of complex bi-directional signaling and cross-talks with other pathways. Further studies are necessary to find a new target for treatment.
促红细胞生成素产生的人肝细胞癌受体（Eph受体）构成跨膜蛋白酪氨酸激酶受体的一个亚家族，参与众多生理和病理过程。Eph家族受体相互作用蛋白（Ephrin）是这些受体的配体。Eph/ephrin系统负责细胞骨架活性、细胞黏附、细胞间连接、细胞形态以及细胞运动。它影响神经元发育和功能、骨骼和葡萄糖稳态、免疫系统以及肠上皮细胞的正常功能。此外，Eph/ephrin系统是血管生成和淋巴管生成的关键系统之一。鉴于其如此广泛的影响，显然该系统功能紊乱会导致病理状态。Eph/ephrin系统参与肿瘤发生和癌症进展。尽管ephrin参与肿瘤发生的观点很明显，但由于复杂的双向信号传导以及与其他途径的相互作用，其确切机制仍不清楚。需要进一步研究以找到新的治疗靶点。
