丙酰辅酶 A 代谢将染色质酰化与心脏转录联系起来。
Propionyl-CoA metabolism links chromatin acylation to cardiac transcription.
机构信息
Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA, USA.
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA.
出版信息
Nat Cardiovasc Res. 2023 Dec;2(12):1109-1111. doi: 10.1038/s44161-023-00381-0. Epub 2023 Dec 4.
Abstract
The molecular mechanisms that link propionyl-CoA metabolism and epigenetic regulation of gene expression are unclear, as are the implications for heart function. Now, new insights into the modulation of chromatin acylation and transcription by aberrant oxidation of propionyl-CoA are revealed in the dysfunctional hearts of mice with propionic acidemia.
摘要
丙酰辅酶 A 代谢与基因表达的表观遗传调控之间的分子机制尚不清楚，其对心脏功能的影响也不清楚。现在，在患有丙酸血症的小鼠功能失调的心脏中，揭示了丙酰辅酶 A 异常氧化对染色质酰化和转录的调节作用。
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