Fisheries Product Technology, Faculty of Agriculture, Universitas Sriwijaya, Indralaya 30862, Indonesia.
Department of Food Science, National Taiwan Ocean University, Keelung City 20224, Taiwan.
Food Funct. 2024 Sep 16;15(18):9357-9367. doi: 10.1039/d3fo04639g.
Diabetes mellitus is a metabolic disease characterized by high blood glucose levels or hyperglycemia. Diabetes causes a decrease in immune function in the human body. has been identified as having anti-inflammatory properties and the ability to improve inflammation. Thus, this study aimed to investigate the function of Matsu water extract (MWE) in mediating the regulation of immune responses and dysregulating the intestinal immune system in hyperglycemia mouse models. The mice were treated with MWE for seven weeks. The results showed that treatment with MWE has the ability to decrease triglyceride and total cholesterol concentrations. MWE also increases the interleukin (IL)-10 concentration and natural killer cell activation. It also improves the phagocytic capacity of monocytes in the colon and the proliferative capacity of lymphocytes in the mesentery. Furthermore, MWE also regulates the IL-6 concentration and the ratio of T helper 17 cells to regulatory T cells. Collectively, this extract can improve dyslipidemia, inflammatory responses, and dysregulation of the intestinal immune system. Therefore, water extract can be used as an alternative treatment to reduce diabetes complications.
糖尿病是一种以高血糖或高血糖为特征的代谢性疾病。糖尿病会导致人体免疫功能下降。 已被证明具有抗炎特性和改善炎症的能力。因此，本研究旨在探讨马祖水提取物（MWE）在调节高血糖小鼠模型免疫反应和肠道免疫系统失调中的作用。将小鼠用 MWE 处理 7 周。结果表明，MWE 具有降低甘油三酯和总胆固醇浓度的能力。MWE 还增加了白细胞介素（IL）-10 浓度和自然杀伤细胞的激活。它还改善了结肠中单核细胞的吞噬能力和肠系膜中淋巴细胞的增殖能力。此外，MWE 还调节 IL-6 浓度和辅助性 T 细胞 17 细胞与调节性 T 细胞的比值。综上所述，这种提取物可以改善血脂异常、炎症反应和肠道免疫系统失调。因此，马祖水提取物可作为一种替代治疗方法，以减少糖尿病并发症。
