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蓝贻贝水提取物改善肥胖大鼠骨关节炎的炎症反应和氧化应激。

Blue Mussel () Water Extract Ameliorates Inflammatory Responses and Oxidative Stress on Osteoarthritis in Obese Rats.

作者信息

Chang Heng-Wei, Sudirman Sabri, Yen Yu-Wen, Mao Chien-Feng, Ong Alan Darmasaputra, Kong Zwe-Ling

机构信息

Department of Food Science, National Taiwan Ocean University, Keelung City 20224, Taiwan.

Fisheries Product Technology, Faculty of Agriculture, Universitas Sriwijaya, Palembang, Ogan Ilir Regency 30862, Indonesia.

出版信息

J Pain Res. 2020 May 21;13:1109-1119. doi: 10.2147/JPR.S244372. eCollection 2020.

DOI:10.2147/JPR.S244372
PMID:32606898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7293401/
Abstract

PURPOSE

To investigate the effects of water extract (MWE) on an anterior cruciate ligament transection and a partial medial meniscectomy surgery to induced osteoarthritis (OA) with the high-fat diet (HFD)-induced obese rats.

METHODS

The male Sprague-Dawley rats were fed with HFD for 4 weeks before surgery. The OA rats were orally administered with MWE (108.5, 217.0, and 542.5 mg/kg) for 6 weeks.

RESULTS

The administration of MWE affected weight loss, triglycerides content, and total cholesterol level. MWE also enhanced the activity of superoxide dismutase and decreased lipid peroxidation degree. Moreover, MWE reduced proinflammatory cytokines level, alleviated inflammation and swelling of the osteoarthritic knee, and reduced loss of proteoglycan in articular cartilage tissue.

CONCLUSION

MWE suppressed proinflammatory mediators and attenuated the cartilage degradation and pain in osteoarthritis rats under obesity condition. Therefore, MWE has the potential to act as an alternative for osteoarthritis treatment.

摘要

目的

研究水提取物（MWE）对高脂饮食（HFD）诱导的肥胖大鼠前交叉韧带横断和部分内侧半月板切除术诱导的骨关节炎（OA）的影响。

方法

雄性Sprague-Dawley大鼠在手术前用高脂饮食喂养4周。OA大鼠口服MWE（108.5、217.0和542.5 mg/kg）6周。

结果

给予MWE影响体重减轻、甘油三酯含量和总胆固醇水平。MWE还增强了超氧化物歧化酶的活性并降低了脂质过氧化程度。此外，MWE降低了促炎细胞因子水平，减轻了骨关节炎膝关节的炎症和肿胀，并减少了关节软骨组织中蛋白聚糖的损失。

结论

MWE抑制促炎介质，减轻肥胖条件下骨关节炎大鼠的软骨降解和疼痛。因此，MWE有潜力作为骨关节炎治疗的替代方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced7/7293401/5b28d83a231f/JPR-13-1109-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced7/7293401/0ff7eadc253c/JPR-13-1109-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced7/7293401/c6ee021a967a/JPR-13-1109-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced7/7293401/4e6ad55ceba4/JPR-13-1109-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced7/7293401/80e1d644e081/JPR-13-1109-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced7/7293401/3e81e390a27e/JPR-13-1109-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced7/7293401/5b28d83a231f/JPR-13-1109-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced7/7293401/0ff7eadc253c/JPR-13-1109-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced7/7293401/c6ee021a967a/JPR-13-1109-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced7/7293401/4e6ad55ceba4/JPR-13-1109-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced7/7293401/80e1d644e081/JPR-13-1109-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced7/7293401/3e81e390a27e/JPR-13-1109-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced7/7293401/5b28d83a231f/JPR-13-1109-g0006.jpg

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